Clinical Trial – Effects of Dexmedetomidine Premedication on Geriatric Patients With Chronic Renal Failure Undergoing Hip Surgery

by HBOT News | Apr 17, 2013 | Chronic Renal Failure, Clinical Trials, HBOT Research

Geriatric patients (age ≥ 65 years) undergo surgery for hip fractures that develops due to
osteoporosis and falls. Dialysis-dependent chronic kidney disease is associated with an
increased risk of cardiovascular comorbidity. Elective or urgent surgical operations may be
required for geriatric patients with end stage renal disease. These patients have severe
comorbidities, fluid, electrolyte disturbances and drug metabolism abnormalities during the
perioperative period. For this reasons a careful anesthesia plan should be planned and
performed. Spinal anesthesia can be used for hip fracture surgery at geriatric patients with
chronic renal failure. Anterograde femoral intramedullary nailing can be performed in supine
position with a fracture table. Intraoperative sedation might be necessary for patients under
regional anesthesia on traction table. Dexmedetomidine is an alpha 2 receptor agonist that is
being used as an agent for its sedative and adjuvant analgesic effects.

The aim of this study is to evaluate the effects of dexmedetomidine premedication on
geriatric patients with end stage renal disease, who will be undergoing a surgical operation
for hip fracture under spinal anesthesia with hyperbaric bupivacaine and BIS (Bispectral
Index) guided sedation with intraoperative propofol infusion.