Stem cell mobilization by hyperbaric oxygen

“We hypothesized that exposure to hyperbaric oxygen (HBO2) would mobilize stem/progenitor cells from the bone marrow by a nitric oxide (NO) -dependent mechanism”

The goal of this investigation was to determine whether exposure to hyperbaric oxygen (HBO2) would mobilize bone marrow-derived stem/progenitor cells (SPCs) in humans and animals.

Stem cell release in humans exposed to HBO2. This protocol was approved by the Institutional Review Board and by the Clinical Trials Scientific Monitoring Committee of the Abramson Cancer Center. Patients are referred to the University of Pennsylvania Institute for Environmental Medicine for prophylactic HBO2 treatment because of a risk for ORN.