Hyperbaric and Normobaric Oxygen in Severe Brain Injury
Description:
Brain injury continues to be a major cause of death and disability throughout the world. Our
investigations of hyperbaric oxygen treatment (HBOT) indicate that it is a relatively safe
treatment that has promise as a potential therapy for patients with severe traumatic brain
injury (TBI). The goals of the present proposal are to further elucidate the mechanisms of
action of HBOT on severe TBI and to test hypotheses that are crucial to the possible future
design of a Phase III clinical trial.
Our initial prospective clinical trial to assess the effectiveness of HBOT in severe TBI
documented very significant improvement in survival, particularly in certain subgroups of
patients. In our second study, HBOT was found to improve cerebral aerobic metabolism in
patients with severe TBI, reduce elevated intracranial pressure, and had a persistent
positive effect for at least six hours following the treatment. Our work suggests that HBOT
allows the brain to utilize increased amounts of oxygen more efficiently following treatment.
Recently, increasing the inspired oxygen concentration (FiO2) to 100% has been proposed as an
alternative way of delivering supranormal levels of oxygen to severe TBI patients.
Experimental investigation in the fluid percussion rat model using HBOT at 1.5 ATA
(atmospheres absolute) for 60 minutes followed by 3 hours of 100%fraction of inspired oxygen
(FiO2) have given optimum results in terms of mitochondrial functional and neurobehavioral
improvement.
The clinical and experimental data together provide a strong basis for the restorative effect
of the combination of hyper- and normobaric hyperoxia on severe TBI. The goal of this study
is to evaluate the use of HBOT and 100% FiO2 separately and in combination.
Condition:
Traumatic Brain Injury
Treatment:
Hyperbaric Oxygen Treatment (HBOT)
Start Date:
November 2002
Sponsor:
Hennepin Healthcare Research Institute
For More Information:
https://clinicaltrials.gov/show/NCT00170352