The Effect of BMI on Median Effective Dose (ED50) of Intrathecal Hyperbaric Bupivacaine for Total Knee Replacement Arthroplasty
Description:
The effect of BMI on requirements of local anesthetics used in spinal anesthesia has not been
well established. The investigators tried to quantify the effect of BMI on spinal anesthesia
by comparing the median effective dose (ED50)of intrathecal bupivacaine between two different
BMI groups. The investigators determined the ED50 and ED 95 of intrathecal hyperbaric
bupivacaine of subjects with BMI below 27.5 kg/m2, and subjects with BMI over 27.5 kg/m2,
respectively. By comparing the difference of ED50 and ED95 between the groups, the
investigators tried to quantify the effect of BMI on the bupivacaine dose requirement.
Condition:
Arthroplasty, Knee
Treatment:
BPV6NO
Start Date:
January 2010
Sponsor:
Seoul Medical Center
For More Information:
https://clinicaltrials.gov/show/NCT01291186