The Effect of Hyperbaric Oxygen Therapy on Inflammatory Parameters Induced by a Heat Injury Model
Description:
Hyperbaric oxygen (HBO) reduces neuropathic pain, promote healing of hypoxic, chronic wounds
and sores caused by radiation therapy. Nitric oxide (NO) is a contributing factor to the
prolonged anti-nociceptive effect of HBO treatment. In addition, HBO stimulates the formation
of reactive oxygen and nitrogen forms, reduces beta-2 integrin function, and reduces contact
of leukocytes to the endothelial surface of the capillaries, improves microcirculation and
causes decreased monocyte chemokine synthesis. It is the interaction of these mechanisms
involved in HBO’s anti-inflammatory effect. How HBO reduces pain and inflammation in humans
has not been established. In healthy subjects, investigators have shown that HBO has a
reducing effect on the mechanism, which at the level the of spinal cord amplifies the number
and and the extension of pain impulses. Subjects who were given HBO therapy initially
developed significantly less secondary hyperalgesia than the control group several weeks
later by the new heat injury suggesting a protective, preconditioning effect. As in the
previous experiment (NCT02025686) preconditioning effects will be assessed by means of
measurements of thermal thresholds, pin-prick thresholds, erythema indices and secondary
hyperalgesic areas (i.e. area under the curve per minute). Similarly,differences in the
sequence of sessions (i.e. first session HBO;second session ambient pressure condition or
first session ambient pressure condition;second session HBO) will be analyzed accordingly. In
an improved blinded study design investigators will now investigate the effect of HBO
treatment using the same cutaneous heat injury model, as in the first study. Investigators
expect to finally be able to confirm previous results thereby improving treatment of severe
pain conditions.
Condition:
Secondary Hyperalgesia
Treatment:
Hyperbaric oxygen
Start Date:
February 2015
Sponsor:
Rigshospitalet, Denmark
For More Information:
https://clinicaltrials.gov/show/NCT02397343