Dosage of Intrathecal Hyperbaric Bupivacaine and the Incidence of Post Spinal Shivering in Cesarean Section: is There a Relation?
Description:
After approval of the ethics committee, department of anaesthesia, Menoufia University and
written informed consent, a hundred full-term pregnant ladies undergoing elective cesarean
section were enrolled in this study.
The pregnant ladies were randomly assigned using a computerised software to one of two
groups, low dose bupivacaine (LB) and high dose bupivacaine (HB), 50 patients each according
to bupivacaine dose. Group LB received low dose bupivacaine (8 mg hyperbaric bupivacaine)
Group HB received high dose bupivacaine (10 mg hyperbaric bupivacaine).
Vital signs including heart rate and mean arterial blood pressure intra-operatively until the
end of surgery.
The severity of shivering was the primary endpoint. Shivering was graded using a scale: 0, no
shivering; 1, piloerection but no visible muscle activity; 2, muscular activity in one group
of muscle; 3, muscular activity in more than one muscle group but not generalized movement;
and 4, shivering involving the movement of the whole body. Shivering score was recorded for
the whole study period.
Condition:
Cesarean Section; Shivering
Treatment:
Low dose bupivacaine 0.5% (8mg)
Start Date:
December 30, 2017
Sponsor:
Menoufia University
For More Information:
https://clinicaltrials.gov/show/NCT03356899