Hyperbaric Oxygen Therapy Effects on Pulmonary Functions
Description:
After signing an informed consent form, the participants underwent a pulmonary function
baseline evaluation. Participants were treated in a multiplace chamber (HAUX-Life-Support
GmbH) for 60 daily sessions, 5 days a week. Each session consisted of 90 minutes of exposure
to 100% oxygen at 2 ATA with 5 minute air breaks every 20 minutes. Participants repeated
their pulmonary function evaluation after the last HBOT session.
Pulmonary function Measurements of pulmonary functions were performed using the MiniSpir
testing apparatus (MIR- Medical International Research, USA). The equipment was calibrated
using a 3-liter syringe before performing measurements according to the manufacturer’s
instructions. Measurements were performed by a trained technician. The forced expiratory
maneuvers were performed as recommended by the guidelines[13].
The forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and peak
expiratory flow rate (PEF) were taken as the highest readings obtained from at least three
satisfactory forced expiratory maneuvers. Mean forced mid-expiratory flow rate (FEF25-75%)
and forced expiratory flow rates at 25, 50 and 75% of FVC expired (FEF25%, FEF50% and FEF75%)
were taken as the best values from flow-volume loops not differing by >5% from the highest
FVC.
Condition:
Oxygen Toxicity
Treatment:
Hyperbaric oxygen therapy
Start Date:
January 2016
Sponsor:
Assaf-Harofeh Medical Center
For More Information:
https://clinicaltrials.gov/show/NCT03754985