Abstract: The purpose of this study was to evaluate the immediate placement of implants and appliance using hyperbaric oxygenation on a 45-year-old male with a history of squamous cell carcinoma of the floor of the mouth. Five Nobel Biocare implants between the mental...
Carcinoma
Clinical Trial – Dose Escalation Study of Hyperbaric Oxygen With Radiation and Chemotherapy to Treat Squamous Cell Carcinoma of the Head and Neck
This research is being done because we do not know the best treatment for advanced Squamous
Cell Carcinoma of the Head and Neck. These cancers have been treated with a combination of
surgery, radiation and chemotherapy in varying combination. When the tumor is inoperable,
radiation therapy is used with or without chemotherapy in the hope of curing the tumor.
Recently, it has become recognized as generalized knowledge that cancer cells are hypoxic
(low oxygen concentration). Because of the low oxygen concentrations, many cancer treatments
have not been successful. The theory behind this study is to give oxygen to patients prior to
chemotherapy and radiation in hopes of generating greater results in killing cancer cells.
The purpose of this study has two main objectives. The primary objective is to determine
patient tolerance to each arm of the trial.
The second objective is to determine the feasibility of treatment delivery and acute
toxicities associated with each regimen.
It is our intention to undertake a randomized and controlled trial should this Phase I trial
prove successful in terms of patient tolerance.
The effect of hyperbaric oxygen therapy on quality of life in oral and oropharyngeal cancer patients treated with radiotherapy.
Abstract: Radiotherapy is used in the setting of curative treatment for head and neck cancer. Xerostomia and related problems occur when major salivary glands are included in the irradiation fields. This reduces quality of life (QOL). Hyperbaric oxygen therapy (HBOT)...
Concurrent chemoradiation for locally advanced oropharyngeal cancer.
Abstract: The aim of this study was to assess the survival, pattern of failure, morbidity, and prognostic factors of concurrent chemoradiation for locally advanced oropharyngeal cancer. A retrospective survey of patients who underwent chemotherapy and radiation for...
Analysis of microvascular free flaps for reconstruction of advanced mandibular osteoradionecrosis: a retrospective cohort study.
Abstract: Previous studies have suggested that radiation therapy does not impact local complication rates after microvascular free flap (MVFF) reconstruction for head and neck cancer. There is little data, however, indicating whether or not the presence of...
Transthoracic esophagectomy and lobectomy performed in a patient with synchronous lung cancer and combined esophageal cancer and esophageal leiomyosarcoma.
Abstract: We report a pitfall deriving from the assumption of metastatic disease based upon seemingly identical histology in a pulmonary lesion and in the esophagus. In a 60-year-old patient, cT1 esophageal squamous cell carcinoma was found. One of the two pulmonary...
Adjunctive hyperbaric oxygen therapy in radiation-induced non-healing wound.
Abstract: Korpinar, Cimsit, Cimsit, Bugra, Buyukbabani, , , , (2006). Adjunctive hyperbaric oxygen therapy in radiation-induced non-healing wound. The Journal of dermatology, 2006 Jul;33(7):496-7. https://www.ncbi.nlm.nih.gov/pubmed/16848825
MR assessment of changes of tumor in response to hyperbaric oxygen treatment.
Abstract: Enhancement of image intensity, using the T1-weighted spoiled gradient-echo (SPGR) sequence, was measured in SCC tumor implanted in the flank of C3H mice while they were subjected to several types of oxygenation challenges inside a hyperbaric chamber...
[Effects of hyperbaric oxygen therapy (HBO) during treatment of infected free bone transplants. A Case report].
Abstract: Hyperbaric oxygen therapy (HBO) leads to a significant increase of oxygen supply in poorly perfused tissue. Several physiological mechanisms of this treatment modality are suitable for having a positive effect on infected large autologous free bone...
Secondary free-tissue reconstruction for metachronous tumors of the head and neck: techniques, results, and outcomes.
Abstract: Malignancies of the head and neck are not uncommon in the Far East due to the habit of betel-nut chewing. The development of a second primary neoplasm is a constant fear for those who have had successful treatment of a primary cancer. A total of 82 patients,...