Approximately 500 patients will be included in this patient registry. Data collection
includes demographics, clinical data of underlying disease and use of bisphosphonates,
denosumab and antiangiogenic drugs , degree and extension of osteonecrosis,
osteonecrosis-specific treatment, outcomes and complications within 1 year after treatment.
Clinical Trials
Clinical Trial – Effects of High-Intensity Interval Training (HIT) While in a Hyperoxic-Hyperbaric Environment on Exercise Performance
Hyperbaric oxygen has previously been tested as a possible means for pre-conditioning to
enhance exercise performance. This study is designed to examine the effects of exercising in
a hyperbaric chamber for improving fitness when combined with high-intensity training.
Clinical Trial – Treatment of Human Cord Blood Mononuclear Cell for Delayed Encephalopathy After Carbon Monoxide Poisoning
The effects and safety of Human cord blood mononuclear cell for delayed encephalopathy after
carbon monoxide poisoning
Clinical Trial – Hyperbaric Oxygen Therapy to Reduce Lymphedema After Breast Cancer -an Explorative Clinical Trial
The purpose of this study is to examine if pressurechamber treatment (HBOT) can reduce early
stages of breast cancer related lymphedema, and to explore the mechanisms involved in the
disease progress.
Clinical Trial – Extra Sitting Time After Spinal Anesthesia for Cesarean Section and Fetal Well-being
After injection of the spinal anesthetic drug, women will be allowed to lie down immediately
(0-30 sec) or after three minutes (180 sec) of sitting. The incidence of maternal hypotension
and fetal umbilical cord blood pH will be recorded.
Clinical Trial – Hyperbaric Oxygen Therapy Improves Outcome of Hypoxic-Ischemic Encephalopathy
The purpose of this study is to to evaluate the safety and efficacy of hyperbaric oxygen in
term gestation newborn infants with hypoxic-ischemic encephalopathy..
Clinical Trial – Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal)
This study aims to determine whether or not spinal anesthesia with the local anesthetic drug,
chloroprocaine, wears off faster than the local anesthetic drug, bupivacaine, and results in
faster discharge from the post-anesthesia care unit after surgery.
Clinical Trial – Pharmacokinetics of Levobupivacaine After Cesarean Section
Transversus abdominis plane (TAP) block provides effective analgesia and is now a standard of
care for analgesia after cesarean section. There is no information on levobupivacaine
pharmacokinetics post TAP after pregnancy.
Objective: Generate a pharmacokinetic levobupivacaine model and its effect on the
electrocardiogram (ECG).
Method: The investigators will study 12 healthy term pregnant patients, scheduled for
elective cesarean section under spinal anesthesia. A bilateral TAP block is performed with 20
ml 0.25% levobupivacaine with epinephrine 5 ug/ml. Sensory block will be assessed at 1-2-6
and 12 hours post puncture. 2 ml of venous blood will be obtained at 2-5-10-30-45-60-90 and
180 minutes. With a Holter machine we will study the effect of levobupivacaine plasma levels
and the QTc changes.
Expected results: 1) Plasma levobupivacaine levels; 2) Changes in QTc .
Clinical Trial – Hyperbaric Bupivacaine Versus Hyperbaric Prilocaine 2% for Cesarean Section Under Spinal Anesthesia
Over the past 15 years, cesarean delivery is most commonly performed under spinal anesthesia
using hyperbaric bupivacaine which provides an adequate sensory and motor block. Despite
effective surgical anesthesia, bupivacaine is associated with long duration motor block and
dose-dependent maternal hypotension potentially harmful for the fetus. Prilocaine with its
new 2% hyperbaric formulation (HP), developed recently, showed rapid onset of action and
faster regression of motor block compared to other local anesthetics without noteworthy
side-effects when used intrathecally. The aim of this randomized, multicenter, powered
clinical trial is to investigate whether HP may be an efficient alternative to hyperbaric
bupivacaine for scheduled caesarean delivery under spinal anesthesia, with more rapid
rehabilitation and less adverse effects. Our hypothesis is that hyperbaric prilocaine offers
shorter motor block and more rapid rehabilitation than bupivacaine.
Clinical Trial – Comparative Study of the Analgesic Effect of Spinal Anesthesia or Infiltration Anesthesia for Hemorrhoidectomy
Background and Objectives: Postoperative analgesia and early recovery are relevant for
hospital discharge after hemorrhoidectomy. This study investigated the postoperative
analgesic effect with local infiltration compared with spinal block.
Methods: This randomized study included 40 patients aged 18 to 60 years old. Local group (LG)
received local infiltration under general anaesthesia; spinal group (SG) received a
subarachnoid block. LG received general anaesthesia with propofol, atracurium and propofol
infusion as well as a local infiltration of 20 ml 0.75% ropivacaine. SG received 2 ml of 0.5%
hyperbaric bupivacaine. Analgesic supplementation was with 50µg of fentanyl for LG and 1%
lidocaine for SG. There were assessed: postoperative pain intensity, sphincter relaxation,
motor blockade of lower limbs, time to discharge, analgesic dose over 1 week and adverse
effects.