Decompression Sickness

Clinical Trial – Decompression Tables for Diving at Altitude

The aims of this proposal are to test current USN procedures for adjusting decompression
procedures during air diving at 8,000 and 10,000 ft altitude and to provide a decompression
algorithm for no-stop dives to 100 feet of sea water (fsw) at 10,000 and 12,000 ft altitude
using enriched O2 (PO2=1.3 ATM). Additionally, the experiments will determine whether a
period of hyperbaric hyperoxia, such as would be experienced during a dive at altitude,
reverses altitude acclimatization, resulting in a return of acute mountain sickness (AMS)
symptoms.

Clinical Trial – Markers of Central Nervous System Injury in Decompression Sickness

Research hypothesis

– There is a correlation between the quantity of fluid markers of CNS injury in blood and
DCS.

– There is a correlation between quantity and kind of fluid markers of CNS injury in blood
and both diving profile and severity of DCS.

– There is a correlation between the quantity of inflammatory markers in blood an DCS.

Objectives:

– Assess whether individuals suffering decompression sickness exhibit fluid markers of
central nervous system injury.

– Evaluate the correlation between quantity and kind of fluid marker of CNS injury and
clinical signs of neurological impairment.

– Evaluate the correlation between quantity and kind of fluid marker of CNS injury and
clinical outcome after 3-6 months.

– Assess whether individuals suffering decompression sickness exhibit inflammatory markers
in blood.

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