Abstract: Complications associated with diabetes are often expensive to treat, and commonly include foot ulceration. While most diabetic foot ulcers heal with standard treatment, when standard treatment measures fail, adjunctive therapies must be considered. We...
Diabetic Foot Ulcers
Clinical Trial – Efficacy of the Combination of Isosorbide Dinitrate Spray and Chitosan in Diabetic Foot Ulcers
The prevalence of diabetic foot ulceration in the diabetic population is 4-10%; the condition
is more frequent in elder patients. It is estimated that about 5% of all patients with
diabetes present a history of foot ulceration, while the lifetime risk of diabetic patients
developing this complication is 15%. The majority (60-80%) of foot ulcers will heal, while
10-15% of them will remain active, and 5-24% of them will finally lead to limb amputation
within a period of 6-18 months after the first evaluation , 2 out of 3 patients with a limb
amputation could also be involved in a new amputation in the next year; higher or in the
other leg , Eighty-five percent of lower-limb amputations in patients with diabetes are
preceded by foot ulceration. The management of chronic diabetic foot ulcers (DFU) suggests
multi-disciplinary approaches including control of diabetes, orthotic shoe wear, off-loading
device, wound care and surgery in selected cases. However, treatment of DFU remains
challenging because of unsatisfactory results from surgical and non-surgical treatments. Many
adjunctive therapies are designed to improve the care of DFU including negative pressure
wound therapy , ultrasound, recombinant human platelet-derived growth factor-BB (rPDGF-BB)
Hyperbaric oxygen and acellular matrix product among others.
Chronic wound repair and healing in older adults: current status and future research.
Abstract: Older adults are more likely to have chronic wounds than younger people, and the effect of chronic wounds on quality of life is particularly profound in this population. Wound healing slows with age, but the basic biology underlying chronic wounds and the...
Clinical Trial – Effectiveness of Aurix Therapy in Diabetic Foot Ulcers
The aim of this trial is to demonstrate the effectiveness of complete wound healing in a
prospective, open-label, randomized trial in which diabetic food ulcers (DFU) will be treated
using Aurix plus Usual and Customary Care (UCC) and compared to a group receiving just UCC as
provided in up to 100 U.S. wound centers
Therapeutic approach to "diabetic foot" complications.
Abstract: The series of ulcers of the lower extremities known as "diabetic foot" is a common complication of diabetes and the chief cause of admission to hospital. The causes may be numerous but the main ones are distal symmetric neuropathy and peripheral...
Bioengineered alternative tissues in diabetic wound healing.
Abstract: New advances in medicine and technology continually change how clinicians treat patients with the aim of improving outcomes. As technology continues to improve, the ability to treat patients will improve as well. Great progress has been made in diabetic...
The use of human amnion/chorion membrane in the clinical setting for lower extremity repair: a review.
Abstract: Unsuccessful healing represents a significant medical dilemma for both patients and clinicians and create a financial burden on the health care system. Despite the efforts of physicians, many injuries fail to heal with standard care alone. For decades human...
Acute pulmonary edema secondary to hyperbaric oxygen therapy.
Abstract: Hyperbaric oxygen therapy (HBOT) has been shown to be effective in the treatment of diabetic ulcers, air embolism, carbon monoxide poisoning and gas gangrene with minimal adverse effects. Very few cases of HBOT causing acute pulmonary edema (PE) has been...
[Plausible solution to prevent major amputation in diabetic foot patients].
Abstract: Diabetes mellitus is one of the leading public health problems in the world. Complications of diabetes mellitus include cardiovascular diseases, retinopathy, neuropathy and diabetic foot, which can in turn lead to lower extremity amputations. This is the...
Appropriate analysis and presentation of data in wound healing studies: should we publish individual patient data?
Abstract: Uzun, Mutluoglu, Yildiz, , , , , , (). Appropriate analysis and presentation of data in wound healing studies: should we publish individual patient data? Wound repair and regeneration : official publication of the Wound Healing Society [and] the European...