Veterans Special Report
Radiation

Clinical Trial – Treatment of Cerebral Radiation Necrosis With GM1, a Prospective Study

Jun 19, 2013 | , , ,

Cerebral radiation necrosis (CRN) is a well-documented late complication of radiation therapy
for cancers, and may have a devastating effect on the patient’s quality of life (QOL).
However,CRN was once regarded as a progressive and irreversible disease, no standard therapy
has been suggested for CRN. In our clinical practice, we have used
monosialotetrahexosylganglioside (GM1)to treat CRN, and found that GM1 can successfully
reverse CRN. So we carried out this prospective study to test the efficacy of GM1 for CRN.

Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo

Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo

Feb 1, 2009 | , , ,

We hypothesized that oxidative stress from hyperbaric oxygen (HBO2, 2.8 ATA for 90 min daily) exerts a trophic effect on vasculogenic stem cells.

The efficacy of hyperbaric oxygen (HBO2) for healing refractory wounds in diabetic patients and those with radiation injuries has been shown in randomized trials, and its utilization is supported by independent evidence-based reviews (6, 10, 20, 32, 38). Mechanisms of action for HBO2 are not clear. The goal of this study was to examine the impact of HBO2 on vasculogenic stem cells in an in vivo animal model.

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