Cerebral radiation necrosis (CRN) is a well-documented late complication of radiation therapy
for cancers, and may have a devastating effect on the patient’s quality of life (QOL).
However,CRN was once regarded as a progressive and irreversible disease, no standard therapy
has been suggested for CRN. In our clinical practice, we have used
monosialotetrahexosylganglioside (GM1)to treat CRN, and found that GM1 can successfully
reverse CRN. So we carried out this prospective study to test the efficacy of GM1 for CRN.