The Efficacy Of Nalbuphine Versus Fentanyl As Additives To Bupivacaine In Spinal Anaesthesia
For Internal FixationI Of Tibia
Pain
Clinical Trial – SOFT Block Versus Spinal Anesthesia in Patientsusing Ilizarov External Fixator
Peripheral nerve block is an ideal choice for lower limb surgery because of the peripheral
site of the surgical procedure and the ability to block pain pathways at multiple levels. On
the contrary to other anesthetic techniques, as spinal or general anesthesia, properly
performed peripheral nerve blocks bypass adverse events as hemodynamic instability and
respiratory complications, properly treat post-operative pain leading to early hospital
discharge. Additional advantages of peripheral nerve blocks are that they can be used in
patients receiving anti-coagulants or lumbosacral disease in addition to avoidance of airway
instrumentation.
Recently, there has been a significant interest in regional anesthesia and peripheral nerve
blockade. This is facilitated by a significant advance of the research in this field and
availability of better equipment facilitating regional anesthesia.The aim of this study was
to assess the efficacy and safety of SOFT block (sciatic-obturator-femoral nerve block
technique) in comparison with spinal anesthesia in patients undergoing surgery for fixation
of open tibial fractures using Ilizarov external fixator.
Clinical Trial – Analgesic Efficacy of Two Adjuvants During Spinal Anaesthesia.
: Pain modulation is very important after operation, particularly for women who undergo
caesarean section. A pain-free postoperative period is essential following a caesarean
section so new mothers may care for and bond with their neonates. The consequences of the
improper pain management which raise the healthcare costs and prolong the recovery process.
Intrathecal adjuvants are often administered during this procedure to provide significant
analgesia, but they may also have bothersome side effects. Intrathecal midazolam and
magnesium sulfate produces effective postoperative analgesia with no significant side
effects.
Objectives: This prospective, randomized, double-blind study was designed to compare the
analgesic efficacy and safety of intrathecal midazolam vs. Magnesium sulfate vs plain
bupivacaine as an adjunct to bupivacaine in pregnancy patients scheduled for elective
caesarean section.
Clinical Trial – Comparison of Regional Anesthesia Techniques After Total Knee Arthroplasty
Comparison of continuous adductor canal block to continuous femoral nerve block in patients
after total knee arthroplasty.
All patients will be anesthetized with spinal anesthesia. Continuous infusion of ropivacaine
with a catheter implemented to the adductor canal or next to the femoral nerve.
The observed goals: pain intensity, the beginning and quality of rehabilitation.
Clinical Trial – Spinal Versus Caudal Analgesia After Pediatric Infra-umbilical Surgery
Caudal analgesia along with general anesthesia is a very popular regional technique for
prolonged postoperative analgesia in different pediatric surgical procedures where the
surgical site is sub-umbilical. Caudal anesthetics usually provide analgesia for
approximately 4-6 hours.
Recently, the use of spinal anesthesia in infants and children requiring surgeries of
sub-umbilical region is gaining considerable popularity worldwide.
– The ease of performance and the safety regarding cardio-respiratory functions makes spinal
anesthesia as an alternative to general anesthesia in infants and children undergoing
surgeries of sub-umbilical regions.
Clinical Trial – Pharmacokinetics of Levobupivacaine After Cesarean Section
Transversus abdominis plane (TAP) block provides effective analgesia and is now a standard of
care for analgesia after cesarean section. There is no information on levobupivacaine
pharmacokinetics post TAP after pregnancy.
Objective: Generate a pharmacokinetic levobupivacaine model and its effect on the
electrocardiogram (ECG).
Method: The investigators will study 12 healthy term pregnant patients, scheduled for
elective cesarean section under spinal anesthesia. A bilateral TAP block is performed with 20
ml 0.25% levobupivacaine with epinephrine 5 ug/ml. Sensory block will be assessed at 1-2-6
and 12 hours post puncture. 2 ml of venous blood will be obtained at 2-5-10-30-45-60-90 and
180 minutes. With a Holter machine we will study the effect of levobupivacaine plasma levels
and the QTc changes.
Expected results: 1) Plasma levobupivacaine levels; 2) Changes in QTc .
Clinical Trial – Transversus Abdominis Plane Block Versus Ilioinguinal Nerve Block for Pain Management in Inguinal Herniorraphy
This study compares efficacy of transversus abdominis plane block and ilioinguinal nerve
block for postoperative pain in patients undergoing inguinal herniorraphy with spinal
anesthesia. One-third of the patients will receive standard postoperative pain
regimen(control group), one-third will receive a transversus abdominis plane block (with
ultrasound guidance) and the last group will receive an ilioinguinal nerve block(with
ultrasound guidance) in addition to standard postoperative pain regimen. This study is a
Randomized prospective open-label controlled study.
Clinical Trial – Hyperbaric Oxygen Therapy Attenuates Central Sensitization Induced by a Thermal Injury in Human Volunteers (HBO)
The hypothesis of this investigation is to observe if HBO have an anti-inflammatory effect in
humans induced by tonic heat stimulation. It has been shown in animal studies with rats that
HBO could reduce the paw edema induced by carrageenan as an inflammatory agent. The authors
are not aware of similar studies in human subjects investigating this effect of HBO. Aim: To
investigate the anti-inflammatory effect of HBO by reducing the hyperalgesia induced by heat
stimulation in healthy subjects and promote future research and understanding of the
anti-inflammatory processes in humans. The primary endpoint is a reduced area of secondary
hyperalgesia after HBO.
Clinical Trial – Selective Unilateral Spinal Anesthesia Versus Selective Sensory Spinal Anesthesia for Knee Arthroscopy Surgery
Background: Selective unilateral spinal anesthesia is the gold standard spinal anesthesia
technique for knee arthroscopy. Selective sensory spinal anesthesia has recently been
validated for this surgery. Both selective techniques are specially indicated for ambulatory
surgery because of PACU fast track, low discharge home time and high patient satisfaction.
This study compares both spinal techniques for knee arthroscopy surgery.
Clinical Trial – Effect of Body Mass Index on the Dose of Intrathecal Hyperbaric Bupivacaine for Elective Cesarean Section
Combined spinal – epidural (CSE) anesthesia is a well established technique used for elective
Cesarean section. As its name suggests, it combines two anesthesia techniques – spinal and
epidural. Adjusting the dose of freezing medication for body size is not as simple as giving
a larger dose to a larger person. This study asks a simple, yet important question: does your
body mass index (BMI) influence the amount of freezing medication needed for adequate CSE
anesthesia for Cesarean section? BMI is a number calculated from your height and weight. In
patients with a higher BMI, freezing medication appears to spread farther (to a higher level)
in the spinal fluid. When freezing is too high, it can cause unwanted side effects.
Therefore, in order to provide optimal spinal anesthesia to patients with a higher BMI, it
may be advisable to administer less freezing medication. In this study, we want to find the
ideal dose of freezing medication for patients with a higher body mass index, and compare it
to the dose found to be ideal for patients with normal body mass index.