Effect of Different Types of Anesthesia on Perioperative Brain Natriuretic Peptide Levels in Parturient Cardiac Patient Undergoing Elective Cesarean Section
Description:
In our study, investigators will detect changes in brain natruretic peptide (BNP) levels in
parturient patients at risk undergoing cesarean section, in relation to type of anesthesia
used, general anesthesia versus spinal anesthesia, in order to evaluate the safety of type of
anesthesia used for this kind of patient.
It is very important to assess and predict risk in the cardiovascular system in such cases. A
number of cardiac indexes for predicting risk have been developed like Goldman Multifactorial
risk index, Eagle’s risk index and Detsky’s cardiac index. It is recommended to evaluate
patients using these indexes and to institute preoperative medical treatment based on the
results. These clinical scoring systems, although simple to use, are somewhat inconvenient
and have limitations in their predictive value, whereas other cardiac investigations such as
exercise or pharmacologic stress imaging are sensitive, but limited in practice by time and
resources. Recently brain natriuretic peptide (BNP) was spotlighted as a predictor for
diagnosing and predicting the prognosis of various heart diseases. BNP is a cardiac hormone
that is synthesized by ventricular myocytes in response to ventricular dysfunction. Recent
studies have demonstrated that elevated serum BNP levels predict first cardiovascular event
and death in the general population. In addition, it has been reported that BNP measured
before major surgery can be used as a predictor of postoperative cardiac complications.
Condition:
General Anesthesia Versus Spinal Anesthesia on BNP Hormone Levels Preoperatively and Postoperatively in Parturient Cardiac Patient Undergoing C.S
Treatment:
G.A Group A:
Start Date:
February 18, 2018
Sponsor:
Cairo University
For More Information:
https://clinicaltrials.gov/show/NCT03460184