Safety and Efficacy of Intrathecally Administered Magnesium Sulfate Added to Morphine and Local Anesthetics for Major Abdominal Cancer Surgery
Description:
Spinal anesthesia is commonly used for the major abdominal cancer surgery because of
decreasing the risks of general anesthesia.The quality and duration of sensory and motor
block and decrease post operative pain is important in the major abdominal cancer surgery and
patient’s content satisfaction. Opioids in high doses and other drug such as clonidine and
neostigmine added to local anesthetics to this purpose, but significant side effects.
Magnesium sulfate block the N- methyle -D- aspartate (NMDA) channels in a voltage-dependent
way to be improve the quality and duration of spinal block. However, the use of magnesium
sulfate safety profile has been documented by histopathological analysis in experimental
studies. Systemic delivery of magnesium sulfate decrease postoperative opioid requirements.
In experimental studies, spinal injection of magnesium sulfate reduces the respond to painful
stimulus in rats.
Condition:
Abdominal Cancer
Treatment:
intrathecal morphine+LA
Start Date:
January 1, 2018
Sponsor:
South Egypt Cancer Institute
For More Information:
https://clinicaltrials.gov/show/NCT03459417