Veterans Special Report

News & Research

Hyperbaric Oxygen Therapy has been used for the better part of two centuries. Search our  arhives below for past HBOT news and research or scroll down for the latest.

The Latest HBOT News & Research

Comment on Fedorko et al. Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A Prospective, Double-Blind, Randomized Controlled Clinical Trial. Diabetes Care 2016;39:392-399.

Jul 27, 2016 |

Abstract: Löndahl, Fagher, Katzman, , , , , , (2016). Comment on Fedorko et al. Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A Prospective, Double-Blind,...

Response to Comments on Fedorko et al. Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A Prospective, Double-Blind, Randomized Controlled Clinical Trial. Diabetes Care 2016;39:392-399.

Jul 27, 2016 |

Abstract: Fedorko, Bowen, Jones, Oreopoulos, Goeree, Hopkins, O'Reilly, , (2016). Response to Comments on Fedorko et al. Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the...

Clinical Trial – Pharmacokinetics of Levobupivacaine After Cesarean Section

Jul 27, 2016 | , , ,

Transversus abdominis plane (TAP) block provides effective analgesia and is now a standard of
care for analgesia after cesarean section. There is no information on levobupivacaine
pharmacokinetics post TAP after pregnancy.

Objective: Generate a pharmacokinetic levobupivacaine model and its effect on the
electrocardiogram (ECG).

Method: The investigators will study 12 healthy term pregnant patients, scheduled for
elective cesarean section under spinal anesthesia. A bilateral TAP block is performed with 20
ml 0.25% levobupivacaine with epinephrine 5 ug/ml. Sensory block will be assessed at 1-2-6
and 12 hours post puncture. 2 ml of venous blood will be obtained at 2-5-10-30-45-60-90 and
180 minutes. With a Holter machine we will study the effect of levobupivacaine plasma levels
and the QTc changes.

Expected results: 1) Plasma levobupivacaine levels; 2) Changes in QTc .

Clinical Trial – Hyperbaric Bupivacaine Versus Hyperbaric Prilocaine 2% for Cesarean Section Under Spinal Anesthesia

Jul 25, 2016 | , ,

Over the past 15 years, cesarean delivery is most commonly performed under spinal anesthesia
using hyperbaric bupivacaine which provides an adequate sensory and motor block. Despite
effective surgical anesthesia, bupivacaine is associated with long duration motor block and
dose-dependent maternal hypotension potentially harmful for the fetus. Prilocaine with its
new 2% hyperbaric formulation (HP), developed recently, showed rapid onset of action and
faster regression of motor block compared to other local anesthetics without noteworthy
side-effects when used intrathecally. The aim of this randomized, multicenter, powered
clinical trial is to investigate whether HP may be an efficient alternative to hyperbaric
bupivacaine for scheduled caesarean delivery under spinal anesthesia, with more rapid
rehabilitation and less adverse effects. Our hypothesis is that hyperbaric prilocaine offers
shorter motor block and more rapid rehabilitation than bupivacaine.