HBOT Conversations:
Laurie Anderson (Part 3)

Healing COVID with HBOT

 

Dr. Laurie is a Doctor of Pharmacy, and a graduate of the University of North Carolina – Chapel Hill (UNC-CH) School of Pharmacy and the Pharmacy Practice Residency Program at the University of California – San Francisco (UCSF).  Dr. Laurie spent many years in clinical practice, first as a neurosurgery clinical pharmacist at UCSF Medical Center and then as a general medicine and critical care clinical pharmacist at Duke Medical Center.  For the past 14 years Dr. Laurie has been working in industry, and is currently a safety scientist in early phase drug development, designing safety strategies for First Time in Human clinical trials.

Through her own journey navigating chronic illness, Dr. Laurie has explored and embraced many forms of alternative and non-traditional medicine to support her body for healing.  She has gravitated towards practitioners and modalities that treat the whole patient, with the mantra that tending to mind, body and spirit is the true key to lasting health.  Over the years, Dr. Laurie has discovered that this often leads to a ‘less is more’ approach. She discovered HBOT when she was struggling to heal from COVID, and now tells anyone who will listen about the power of oxygen and pressure.

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We continue Dr. Laurie Anderson’s HBOT News Network interview, diving in deeper to discuss our veteran population, does HBOT have a therapeutic index, and what is the research telling us about the HBOT industry.

Her interview has been released as a three part series. Part 1 and Part 2 has already been released with both focusing on her HBOT journey with COVID & Lyme Disease.

In Part 3 of Laurie’s podcast the conversation shifts.  It starts with the medical industry and the unfortunate “bad rap” that Hyperbaric Oxygen sometimes receives. Dr, Laurie refers to HBOT as a gift, so it’s truly unfortunate when the media focuses on the negative instead of the positive, influencing the public to not even try this life saving therapy.  Research trials are discussed, including the problems that the hyperbaric industry has identified in the sham, placebo and/or control group when researchers try to mimic HBOT with little pressure and they discover that everyone starts to improve. Those of us in this industry understand and effortlessly work to enlighten others that any amount of pressure is good and therapeutic.

The topic of our US military and the high rate of suicide among our service man and women arises.  Is there a solution to the veteran suicide epidemic our country is facing?  It appears there is.  di Girolamo speaks of Patriot Hyperbarics in Tulsa, and the success they have had treating veterans with Hyperbaric Oxygen Therapy.

“The Patriot Clinics in Tulsa treated some 500 veterans with PTSD, with donated money, donated chambers, and healed them. Most of them war-fighters, were in a bedroom, locked in the dark for years and years, like seven, ten years. And then they found Patriot Clinics and they got 40 treatments and then they got their executive function back. Some of them starting businesses. I saw videos of guys, you know, in the car on their way to the clinic on the first day and then on the 40th day, talking about their experience, it was just amazing.
There wasn’t some combined study about that. 500 souls were saved that didn’t commit suicide, they worked their way out of it.”

Dr. Laurie, who is a Doctor of Pharmacy, brings up an excellent point, and one that we’ve never discussed before on HBOT News.  We know that the FDA ultimately states that oxygen is a drug, and you are required to have a prescription for it.  But does Hyperbaric Oxygen have a therapeutic index like other drugs? And if so… how would a patient know they have reached the therapeutic index and how long is a patient at the therapeutic index? She explains it like this…

“If I apply this to drugs, like with a drug we would want to keep the level, generally, we try to keep the level of a drug in the blood inside the therapeutic index, right? So sometimes, depending on the half life of the drug, you can be in your therapeutic index by taking it once a day so you trickle up and down in between that therapeutic index. Some drugs have a shorter half life and you have to take it twice a day to stay in that therapeutic index.
So what keeps you in whatever is the defined therapeutic index, if that can be translated to oxygen therapy, you know, is it daily? Is it twice a day?”

di Girolamo wonders if in 20 years from now the industry will look back on this conversation and be shocked that we weren’t more focused on the therapeutic index. He stresses that the hyperbaric industry can’t even come together and decide the specific definition of hyperbaric oxygen, much less all these variables that Dr. Laurie has opened our eyes to. 

Dr. Laurie ends her time here with HBOT News stressing that for her HBOT healed her during a very sick time with COVID, and it helped her with many of the Lyme Disease symptoms she struggled with for years.  It worked for her, and she said it’s definitely worth a try to see if it can work for you.

 

Guests

Elena Schertz, NP

Dr. Laurie Anderson, Pharm.D.

Dr. Laurie is a Doctor of Pharmacy, and a graduate of the University of North Carolina – Chapel Hill (UNC-CH) School of Pharmacy and the Pharmacy Practice Residency Program at the University of California – San Francisco (UCSF).  Dr. Laurie spent many years in clinical practice, first as a neurosurgery clinical pharmacist at UCSF Medical Center and then as a general medicine and critical care clinical pharmacist at Duke Medical Center.  For the past 14 years Dr. Laurie has been working in industry, and is currently a safety scientist in early phase drug development, designing safety strategies for First Time in Human clinical trials.

Through her own journey navigating chronic illness, Dr. Laurie has explored and embraced many forms of alternative and non-traditional medicine to support her body for healing.  She has gravitated towards practitioners and modalities that treat the whole patient, with the mantra that tending to mind, body and spirit is the true key to lasting health.  Over the years, Dr. Laurie has discovered that this often leads to a ‘less is more’ approach.

When not working, Dr. Laurie is an avid gardener, ballroom dancer and traveler with her husband. Remaining curious and finding joy in every day are her super powers.

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Recent HBOT News

Clinical Trial – HBOT Global Functioning After Stroke

Stroke is one of the leading causes of disability and death in North America and Europe. Up
to 30% of stroke survivors never recuperate completely and suffer from loss of function and
poor quality of life. To improve recovery after stroke, innovative interventions should be a
priority.

Hyperbaric oxygen therapy (HBOT) is an intermittent inhalation of 100% oxygen in a hyperbaric
chamber at a pressure higher than 1 absolute atmosphere (ATA). There is a growing body of
evidence that HBOT can enhance ability of brain to changes its structure (neuroplasticity) in
order to recover. Exercise program during HBOT can augment the effect. Although, recent
randomized controlled trials in patients with chronic brain injury showed promising results,
there are no studies demonstrating combine effect HBOT and exercise rehabilitation program on
stroke recovery.

The proposed study investigates feasibility, safety and efficacy of using a combination of
HBOT and exercise program to improve arm function recovery in chronic stroke patients. In
this pilot randomized control trial, investigators will compare the combination of HBOT and
the focused rehabilitation exercise program versus exercise program alone on recovery of arm
function in patients with chronic stroke.

Clinical Trial – Hyperbaric Oxygen Therapy and Acute Kidney Injury

Kidney injury is a serious complication of cardiac surgery that occurs in up to 30% of
patients and increases the risk of adverse outcomes. Kidney injury initiates when oxygen
supply to the kidney drops below levels that are needed for normal cellular function, causing
tissue oxygen deficiency (hypoxia), activation of the inflammatory cascade, and oxidative
stress. Together, these events further impair tissue oxygenation, culminating in impaired
kidney function due to cellular injury and death.

There are no effective therapies for kidney injury after cardiac surgery, but there is
evidence that recovery is possible if the processes of injury – i.e., impaired oxygen
delivery, increased inflammatory response, and oxidative stress – are ameliorated soon after
the onset of injury. Hyperbaric oxygen therapy (HBOT) – which entails the intermittent
inhalation of 100% oxygen in a hyperbaric chamber at a pressure higher than one absolute
atmosphere (> 760 mmHg) – has been shown to positively affect all of these processes (i.e.,
to improve tissue oxygenation, reduce inflammation, and reduce oxidative stress). Thus, we
hypothesized that HBOT will reduce the severity of kidney injury after cardiac surgery if it
is initiated soon after onset of injury. This hypothesis has not been tested in humans, but
is supported by animal studies.

In this first-in-human, unblinded, controlled pilot trial, 20 adult patients who develop
severe kidney injury soon after cardiac surgery will be randomized (after obtaining informed
consent from the patient or surrogate) to standard-of-care or early HBOT. Severe kidney
injury will be defined as a ≥30% drop in kidney function within 6 hours of surgery (as
determined by change in creatinine from before surgery to Intensive Care Unit (ICU)
admission). This degree of injury occurs in ~ 2% of patients and is associated with a 12-fold
increase in the risk of complete kidney failure (requiring dialysis) or death. Patients will
be excluded if they have any relative or absolute contraindications to HBOT (e.g., severe
ventricular dysfunction, ventricular assist device, severe respiratory dysfunction,
pneumothorax, bronchospasm).