Clinical Trial – Hyperbaric Oxygen Therapy for Adult Onset Post Traumatic Stress Disorder

Posttraumatic stress disorder (PTSD) is the long term effect of severely distressing
traumatic event characterized by intrusive thoughts, nightmares, and avoidance. Brain imaging
of PTSD patients demonstrate alterations in regional brain perfusion, with stunned,
hypoperfused regions. Those brain-biological pathologies may be responsible for the limited
success rate of currently available interventions.

During the last years data regarding Hyperbaric Oxygen Therapy (HBOT) induced neuroplasticity
accumulated. A number of studies in traumatic brain injury, cerebrovascular attacks, and
fibromyalgia have presented evidence of improved perfusion and recovery of metabolic brain
tissues, accompanied by clinical improvement under HBOT even years after the acute insults.

Considerable evidence supports potential benefit of HBOT on PTSD, however, no clinical trial
was done on this pure PTSD population. The aim of the proposed study is to examine hyperbaric
oxygen therapy as a treatment for PTSD. Advanced brain imaging and functional analysis tools
will be used to evaluate treatment’s effect.

Clinical Trial – Hyperbaric Oxygen Therapy Effect on Post Concussion Syndrome in Children

Due its high incidence, mTBI and its consequences of PPCS are a major public health issue.
There is no consensus regarding the treatment of PPCS in pediatrics. Relying on its results
in adults, HBOT offers a promising new direction of treatment, which targets the basic
pathological processes responsible for post-concussion symptoms.

The effect of hyperbaric oxygen therapy in pediatric TBI has never been evaluated.

The aim of the current study is to evaluate in a prospective cross-over, randomized study,
the effect of HBOT on children with PPCS due to mild TBI.