A retrospective study of outcomes in subjects of head and neck cancer treated with hyperbaric oxygen therapy for radiation induced osteoradionecrosis of mandible at a tertiary care centre: an Indian experience.

Abstract: Osteoradionecrosis (ORN) of the mandible is a rare complication of radiation therapy for head and neck cancer. It manifests as an area of exposed necrotic bone failing to heal for at least 3 months. Our study aims to determine the effectiveness of HBO in...

Clinical Trial – Optical Coherence Tomography for Monitoring Late Oral Radiation Toxicity After Radiotherapy of Head and Neck Cancer Patients

Radiation therapy of the head and neck cancer patients causes late oral radiation
complications such as xerostomia (dry mouth) or mucosal atrophy. Currently, methods such as
hyperbaric oxygen are used to treat these complications; however, there are no quantifiable
means of assessing the outcome of these methods. At present, subjective methods such as
superficial examination of the oral cavity are used, yet complications are known to mostly
start in the subsurface layers. In this feasibility study, we apply an imaging technique
called optical coherence tomography (OCT) as a means of providing objective and quantifiable
images of the subsurface micro-structural and micro-vascular changes of oral tissue.
Depth-resolved, micrometer-resolution OCT images provide information on changes associated
with late radiation complications.