Fournier’s gangrene: early diagnosis. How to diagnose, how to manage it.
Abstract: Fournier’s gangrene (FG) is a rare surgical emergency and a life-threatening condition with a rapidly progressive gangrene defined as a necrotizing fasciitis of the perineal or genital areas leading to septic shock and death if untreated. Risk factors...Clinical Trial – Does Hyperbaric Oxygen Therapy Lead to a Sustained Increase in Insulin Sensitivity?
In a recent series of studies performed by our group, we have shown that exposure to
hyperbaric oxygen (HBOT) leads to an increase in insulin sensitivity in male subjects and
that this improvement can be measured in all men, not just those with diabetes. The aim of
this study is to investigate the time course of this effect and explore the mechanisms
involved when exposure to HBOT induces an increase in peripheral insulin sensitivity.
Aims:
1. To determine whether the insulin sensitising effect of HBOT is apparent 24-hours after
an HBO session.
2. To examine mechanisms underpinning the increase in insulin sensitivity following HBOT.
The relationship of decongestant use and risk of decompression sickness; a case-control study of Hawaiian scuba divers.
Abstract: Exposure to cold, dehydration, and aging are known to contribute to the development of decompression sickness (DCS) in divers. Hypertension and nicotine usage have also been suggested as risk factors. Vasoconstriction is an underlying mechanism associated...Clinical Trial – Hyperbaric Oxygen Therapy and Insulin Resistance (HOTAIR2) – Effect of One HBO Session.
Obesity is an epidemic in Western society and is the biggest risk factor for insulin
resistance and type 2 diabetes. The investigators have recently shown that exposure to
hyperbaric oxygen (HBO) leads to an increase insulin sensitivity in males ubjects and that
this improvement can be measured in all men, not just those with diabetes. The aim of this
study is to investigate the time course of this effect and explore the mechanisms involved.
The investigators suspect that insulin sensitivity as measured by
hyperinsulinaemic-euglycaemic clamp will be increased within the time-frame of one 2-hour
hyperbaric oxygen exposure, and that the improvement will be measurable in females as well as
males.