Clinical Trial – A Randomized Phase II Study of Hyperbaric Oxygen in Improving Engraftment in Umbilical Cord Blood Stem Cell Transplant

The UCB transplant is a type of stem cell transplant used to treat cancer of the blood or
lymph glands. The UCB transplant has advantages over other types of transplants such as ease
of obtaining the umbilical cord blood, absence of donor risks, reduced risks of contagious
infections, and the availability for immediate use. The UCB transplant is also associated
with a lower incidence of graft versus host disease, or GvHD (in GvHD, the transplanted graft
attacks the recipient organs).

Umbilical cord-derived mesenchymal stem cell transplantation combined with hyperbaric oxygen treatment for repair of traumatic brain injury.

Transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) for repair of traumatic brain injury has been used in the clinic. Hyperbaric oxygen (HBO) treatment has long been widely used as an adjunctive therapy for treating traumatic brain injury. UC-MSC transplantation combined with HBO treatment is expected to yield better therapeutic effects on traumatic brain injury. In this study, we established rat models of severe traumatic brain injury by pressurized fluid (2.5-3.0 atm impact force). The injured rats were then administered UC-MSC transplantation via the tail vein in combination with HBO treatment.