Clinical Trial – Outcome Following Carbon Monoxide Poisoning in Children

Carbon monoxide poisoning is common. Many adults with CO poisoning have long-term, even
permanent brain injury following poisoning. However, very little is known about the long-term
outcome of children with carbon monoxide (CO) poisoning. In this study we plan to perform
cognitive (thinking) and vestibular (balance) testing in children (ages 6 to 16)at 6 weeks
and 6 months following CO poisoning.

At the 6-week visit, if the child and parents agree, we will ask each child to provide a DNA
sample by one of three methods: mouthwash, spit collection, or swabbing the inside of the
child’s cheek. Each child’s DNA will be analyzed for genes that are known to affect outcome
following brain injury.