The blinded RCTstudy aims to:

– Determine the effects of HBOT on burns conversion for patients who have fresh thermal
burns injury using the LDI.

– Objectively determine the proportion of burns conversion in areas of partial thickness
burns for early thermal burns injury in both arms of the RCT.

– Study the effects of HBOT on immunological markers IL-1, IL-2, IL-4, IL-6, IL-8, IL-10,
TNF-α and TGF-β ( comparison between both arms and 2 assessment points).

– Study the effect of HBOT on haematological markers including procalcitonin ,albumin,
lymphocyte counts, neutrophil count, and macrophage count.

– Study the effects of HBOT on histology specimens in quantifying P53 protein, leukocyte
and macrophage infiltration, burns depth assessment and vascular endothelial growth
factor (VEGF) and inducible nitric oxide synthase (iNOS) .

– Study the effects of HBOT on bacteriology of tissue culture in areas of deep dermal
burns.