Osteoradionecrosis, dermal soft tissue necrosis, radiation cystitis, proctitis and sexual
dysfunctions are well-known late-effects after radiation for cancer in the pelvic area,
negatively affecting the survivors’ quality of life (QOL) and psychosocial wellbeing.
Increasing evidence and clinical practice support the use of hyperbaric oxygen treatment
(HBOT) as an effective treatment in a variety of radiation injuries, but this is still a
field with limited research and knowledge. Especially, there is a knowledge gap on how late
radiation tissue injury (LRTI) influences cancer survivors’ QOL and psychosocial health in a
longitudinal perspective (before, along and after HBOT), as well as the patients’ knowledge,
expectation and experience from this treatment. This study aims to improve knowledge on these
issues.
Cancer
Hyperbaric oxygenation for tumour sensitisation to radiotherapy.
Abstract: Cancer is a common disease and radiotherapy is one well-established treatment for some solid tumours. Hyperbaric oxygenation therapy (HBOT) may improve the ability of radiotherapy to kill hypoxic cancer cells, so the administration of radiotherapy while...
Magnitude of benefit for adjuvant radiotherapy following minimally invasive surgery in intermediate to high risk HPV-positive oropharyngeal squamous cell carcinoma.
Abstract: To determine the outcomes and toxicities of minimally-invasive surgery with adjuvant intensity-modulated radiotherapy +/- chemotherapy (AT) compared to definitive surgical therapy (ST) in a contemporary cohort of HPV-positive oropharyngeal squamous cell...
Long non-coding RNA LINC00152 promotes cell growth and invasion of papillary thyroid carcinoma by regulating the miR-497/BDNF axis.
Abstract: Long intergenic non-coding RNA 152 (LINC00152) was reported to be tightly linked to tumorigenesis and progression in multiple cancers. However, its biological role and modulatory mechanism in papillary thyroid carcinoma (PTC) has not been elucidated. In this...
Incense burning smoke sensitizes lung cancer cells to EGFR TKI by inducing AREG expression.
Abstract: Incense burning is common in Asian countries due to the religious beliefs. Environmental exposure to incense burning smoke is a potential risk factor for tumor development and progression of non-small cell lung cancer (NSCLC). Eastern Asia ethnic origin is...
Osteoradionecrosis in Subaxial Cervical Spine – a Rare and Devastating Complication: A Case Report.
Abstract: Osteoradionecrosis, a rare complication of radiation therapy, is a slow progression disease which affects the surrounding structures of spinal components. It essentially weakens the soft tissue and bony configuration and can cause nerve impingement or cord...
Experimental observation of hyperbaric oxygen combined with radioactive seed implantation in the treatment of nude mice bearing esophageal squamous cell carcinoma.
Abstract: Objective: To investigate the effect and mechanism of hyperbaric oxygen combined with radioactive seed implantation in the treatment of esophageal squamous cell carcinoma. Methods: Subcutaneous tumor model of esophageal squamous cell carcinoma using TE-8...
Laser and light therapy for treatment of radiation dermatitis.
Abstract: Radiation dermatitis (RD), an inflammatory skin disease that can be an unwanted side effect of medical radiation therapy (RT), most commonly occurs in patients undergoing cancer of the ENT, anal, and vulvar regions. The side effects on the skin and mucous...
Clinical Trial – Effects of Hyperbaric Oxygen (HBO) on Blood Count Recovery After Autologous Hematopoietic Stem Cell (HSPC) Transplant for Multiple Myeloma
Patients with Multiple Myeloma who are considered for high-dose therapy and autologous
transplantation at the bone marrow transplant clinic at the Wilmot Cancer Institute (WCI)
will be be approached to participate in this trial. Eligible patients who choose to
participate will be randomized so that half receive one hyperbaric oxygen therapy session
prior to hematopoetic stem cell infusion and half will not. All subjects will have their
blood counts monitored closely and time to count recovery will be compared between the two
groups.
Multi-Modal Treatment of Rhinocerebral Mucormycosis in a Pediatric Patient with Relapsed Pre-B Acute Lymphoblastic Leukemia.
Abstract: A 17-year-old female developed invasive rhinocerebral mucormycosis during intensive re-induction chemotherapy for relapsed pre-B acute lymphoblastic leukemia. Due to the high case fatality rate for invasive mucormycosis in profoundly immunosuppressed...