We would like to see if Hyperbaric Oxygen can help improve the symptoms that result from Post
Concussive Syndrome.
Clinical Trials
Clinical Trial – A Study to Investigate Two Atteris Antimicrobial Products on Chronic Wound Healing.
This is a 2-part pilot study to determine the clinical effectiveness of two new antimicrobial
products on the complete healing of chronic wounds.
Clinical Trial – Effect of Bilateral Quadratus Lumborum Block for Pain Relief in Patients With Cesarean Section
Cesarean section commonly induces moderate to severe pain for 48 hours. These patients have
additional compelling reasons to provide adequate pain relief as early mobilization is a key
factor to prevent the risk of thromboembolic event which is increased during pregnancy.
Beside these, patients need to be pain free to takecare for their newborn and breastfeed
them. Poorly controlled pain after cesarean section also increases risk of chronic pain and
postpartum depression.
Intrathecal morphine is considered the "gold standard" for postoperative pain relief after
cesarean delivery. The duration of analgesic effect of morphine extend to 12-24 hours. Its
widespread use is due to its favorable pharmacokinetic profile, ease of administration and
low cost. Although intrathecal morphine is highly effective, its use is associated with
undesirable adverse effect particularly nausea, vomiting and pruritus which reduce overall
patients’ satisfaction. More serious complication is the risk of delayed maternal respiratory
depression.
The Quadratus Lumborum block was first described in 2007 which demonstrates a spread to the
paravertebral space, thus leads to a more extensive block to T5-L1 nerve branches and a long
lasting block with the potential to provide visceral pain relief. Therefore, this block has
an evolving role in postoperative analgesia for many lower abdominal surgeries. As the safety
is concerned, there has been one report of a patient with unilateral hip flexion and knee
extension weakness leading to unplanned overnight admission following lateral quadratus
lumborum block after laparoscopic gynaecological operation.
If the result favors effective, it will have the advantage of a combination with intrathecal
opioid to prolong the pain free period after cesarean section which has about 4,000 cases per
year.
Clinical Trial – Inflammatory and Cerebrospinal Biochemical Markers in Blood During Prolonged Hyperbaric Exposure
Research hypothesis
– Prolonged hyperbaric exposure will affect the central nervous system
– Prolonged hyperbaric exposure will induce inflammatory changes
– Prolonged hyperbaric exposure will affect fluid regulation in the body
Objectives:
– To investigate the presence of cerebrospinal biochemical markers in blood during
prolonged hyperbaric exposure
– To investigate changes in the quantity of cerebrospinal biochemical markers in blood
during decompression after prolonged hyperbaric exposure
– To investigate the presence of inflammatory markers in blood during prolonged hyperbaric
exposure
– To investigate changes in the quantity of inflammatory markers in blood during
decompression after prolonged hyperbaric exposure
– To investigate if prolonged hyperbaric exposure alters fluid balance in the body
Clinical Trial – Markers of Central Nervous System Injury in Decompression Sickness
Research hypothesis
– There is a correlation between the quantity of fluid markers of CNS injury in blood and
DCS.
– There is a correlation between quantity and kind of fluid markers of CNS injury in blood
and both diving profile and severity of DCS.
– There is a correlation between the quantity of inflammatory markers in blood an DCS.
Objectives:
– Assess whether individuals suffering decompression sickness exhibit fluid markers of
central nervous system injury.
– Evaluate the correlation between quantity and kind of fluid marker of CNS injury and
clinical signs of neurological impairment.
– Evaluate the correlation between quantity and kind of fluid marker of CNS injury and
clinical outcome after 3-6 months.
– Assess whether individuals suffering decompression sickness exhibit inflammatory markers
in blood.
Clinical Trial – Dexmedetomidine and Laparoscopic Surgery
Conventionally General anaesthesia remains the choice for the majority of open abdominal
surgical procedures, and regional anaesthesia is preferred only for patients who are at high
risk under general anaesthesia . The main reason for selecting spinal anaesthesia as the
first choice for laparoscopic cases was its advantages over general anaesthesia which include
uniform total muscle relaxation, a conscious patient, economical, relatively uneventful
recovery, pain free early postoperative period and the protection from potential
complications of general anaesthesia. The main debatable point, however, seems to be the
status of respiratory parameters among the two modes of anaesthesia during laparoscopic
surgery. In this context it can be stated that spontaneous physiological respiration during
spinal anaesthesia would always be better than an assisted respiration as in general
anaesthesia.
The pneumo-peritoneum induced rise in intra-abdominal pressure including pressure on the
diaphragm and carbon dioxide induced peritoneal irritation are the factors to be considered
Clinical Trial – Spinal Marginally Hyperbaric Ropivacaine for Cesarean Delivery
BACKGROUND: One previous study has confirmed that the marginally hyperbaric solutions of
bupivacaine can maintain good quality of anesthesia and get a more steadily hemodynamic
status than commonly hyperbaric solutions, some authors confirmed the plain ropivacaine for
cesarean section have a higher failure rate and commonly hyperbaric solutions of ropivacaine
have a higher incidence of side reaction. It is unclear what the efficacy of spinal
marginally hyperbaric ropivacaine for elective cesarean delivery.We hypothesized that the
marginally hyperbaric ropivacaine will get a similar efficacy to commonly hyperbaric
solutions but a more steadily hemodynamic status.
OBJECTIVE In this prospective, randomized, double-blinded study, Investigator will compare
the clinical efficacy and adverse effect of spinal anesthesia with commonly hyperbaric and
marginally hyperbaric ropivacaine for elective cesarean delivery.
Main outcome measures: The maximum cephalad sensory block level; the change of continuous
cerebral oxygen desaturation (ScO2) over time; the incidence of hypotension and nausea and
vomiting; the change of invasive arterial pressure; the consumption of ephedrine; the
incidence of shivering; the onset time to T8 dermatome; the quality of anesthesia (efficacy
of motor block and sensory block)
Clinical Trial – Comparison of Regional Anesthesia Techniques After Total Knee Arthroplasty
Comparison of continuous adductor canal block to continuous femoral nerve block in patients
after total knee arthroplasty.
All patients will be anesthetized with spinal anesthesia. Continuous infusion of ropivacaine
with a catheter implemented to the adductor canal or next to the femoral nerve.
The observed goals: pain intensity, the beginning and quality of rehabilitation.
Clinical Trial – Evaluation of Hyperbaric Oxygen Therapy on Wound Healing Following Management of Soft Tissue Sarcoma With Neo-Adjuvant Radiation and Surgical Resection
A prospective, randomized investigation with appropriate power would determine whether or not
postoperative hyperbaric oxygen therapy improves wound healing in patients with soft tissue
sarcoma undergoing surgical resection with neo-adjuvant radiation therapy.
Clinical Trial – Hyperbaric Oxygen Therapy for Inflammatory Conditions of the Urinary Bladder
Pilot study to determine feasibility for treating patients with two chronic inflammatory
conditions of the urinary bladder: chronic interstitial cystitis and recurrent urinary tract
infections using a standardized hyperbaric oxygen treatment plan. Presently there are no good
treatments for these conditions and hyperbaric oxygen may be a safe and readily accessible
therapy as it has proven successful an another type of chronic inflammatory condition of the
urinary bladder known as "radiation cystitis". The study will determine if patients will
consider this an acceptable treatment for their conditions and that it is well tolerated.