The purpose of this innovative adaptive phase II trial design is to determine the optimal
combination of hyperbaric oxygen treatment parameters that is most likely to demonstrate
improvement in the outcome of severe TBI patients in a subsequent phase III trial.
Clinical Trials
Clinical Trial – Use of Intrathecal Fentanyl and Development of Hyperalgesia in Patients Undergoing Elective Cesarean
Opioid analgesic drugs are the main treatment of patients during anesthesia. Although highly
effective, their use is not without problems. One is the increasing requirement of these
address the same nociceptive stimulus.
Opioid induced hyperalgesia could be an explanation studies in animal models. Through
mechanisms where N-methyl-D-aspartate receptors, glutamatergic system disturbances and
changes in intracellular calcium regulation involved.
The hyperalgesia induced by intrathecal opioids is controversial. The investigators propose a
model study in patients undergoing cesarean section to study the secondary hyperalgesia
induced based on the study of nociceptive thresholds with two methods opioids: Von Frey
filaments and digital algometer.
If intrathecal fentanyl is used in spinal anesthesia for elective cesarean section, then, an
increase in sensitivity will occur. This increase can be measured by von Frey filaments,
expressed in increased requirement clinically opioids.
Clinical Trial – Spinal Anesthesia Versus Combined Sciatic-femoral Nerve Block for Outpatient Knee Arthroscopy
The aim of the study is to compare the time of home discharge in day-case patients receiving
either a spinal anesthesia or a combined sciatic-femoral nerve block for knee arthroscopy
Clinical Trial – Transversus Abdominis Plane Block Versus Ilioinguinal Nerve Block for Pain Management in Inguinal Herniorraphy
This study compares efficacy of transversus abdominis plane block and ilioinguinal nerve
block for postoperative pain in patients undergoing inguinal herniorraphy with spinal
anesthesia. One-third of the patients will receive standard postoperative pain
regimen(control group), one-third will receive a transversus abdominis plane block (with
ultrasound guidance) and the last group will receive an ilioinguinal nerve block(with
ultrasound guidance) in addition to standard postoperative pain regimen. This study is a
Randomized prospective open-label controlled study.
Clinical Trial – Does the Addition of Epinephrine Prolong the Duration of Spinal Anesthesia for Repeat Cesarean Section?
The purpose of this study is to investigate whether the addition of a medication called
epinephrine to spinal medications prolongs the duration of the anesthesia. The medication
standardly used in spinal anesthesia is a local anesthetic (bupivacaine) and an opiate pain
medication (morphine). These medications typically last about 2 hours. The investigators want
to determine if adding epinephrine to the spinal medications prolongs the anesthetic without
side effects. A longer duration of anesthesia may be useful in prolonged repeat cesarean
section. Epinephrine is known to prolong the action of some local anesthetics, but the
investigators want to specifically study combining it with the medications the investigators
use regularly for cesarean section.
You may qualify to take part in this research study because you are having a repeat cesarean
section. Repeat cesarean sections sometimes last longer than 2 hours. The investigators want
to determine if epinephrine will prolong the anesthetic.
Clinical Trial – Hyperbaric Oxygen Therapy for Lung Transplantation
The objective of this study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) on
airway complications in post-lung transplant recipients with evidence of restricted levels of
blood and oxygen in the airway tissue. Study subjects with extensive airway tissue damage in
the early post-transplant period will be randomized to HBOT or usual care and followed
clinically for 12 months following randomization. The investigators hypothesize that HBOT
will decrease the number of airway complications in the treated subjects.
Clinical Trial – Hyperbaric VO2max Study
This study seeks to examine the effectiveness of training while in a hyperoxic-hyperbaric
environment for exercise performance at altitude. Subjects will complete a short,
high-intensity interval training (HIT) program inside the hyperbaric chamber.Before and after
this training phase, all subjects will be tested for maximum aerobic capacity at a simulated
high altitude of 15,000ft in a hypobaric chamber, as well as for molecular markers of
mitochondrial oxidative capacity in a skeletal muscle biopsy.
A group of individuals of similar characteristics completing this training program in a
normoxic-normobaric environment will serve as a control.
Clinical Trial – Effectiveness of Aurix Therapy in Venous Leg Ulcers
The aim of this trial is to demonstrate the effectiveness of complete wound healing in a
prospective, open-label, randomized trial in which venous leg ulcers (VLU)n will be treated
using Aurix and compared to patients receiving undefined Usual and Customary Care (UCC)
Clinical Trial – Effectiveness of Aurix Therapy in Pressure Ulcers
The aim of this trial is to demonstrate the effectiveness of complete wound healing in a
prospective, open-label, randomized trial in which pressure ulcers will be treated using
Aurix and standard care and compared 1:1 to patients receiving undefined Usual and Customary
Care.
Clinical Trial – Effectiveness of Aurix Therapy in Diabetic Foot Ulcers
The aim of this trial is to demonstrate the effectiveness of complete wound healing in a
prospective, open-label, randomized trial in which diabetic food ulcers (DFU) will be treated
using Aurix plus Usual and Customary Care (UCC) and compared to a group receiving just UCC as
provided in up to 100 U.S. wound centers