The purpose of the research study is to collect information about brain function and
structure among active duty military personnel or civilians who are healthy. Researchers want
to develop a database from normal volunteers that will be used in comparison with a similar
database from active duty military with post-concussive syndrome (PCS) from a mild traumatic
brain injury. Findings from this study may be used to design larger studies that will
evaluate whether hyperbaric oxygen treatments actually improve PCS.
Participants in this study will undergo numerous tests to assess physical, mental, and
intellectual health and how they might change over time. Participants will wear heart and
activity monitors, undergo brain imaging, provide blood and urine for laboratory testing, and
have vision, hearing, balance, and muscle function tests. They will also complete a number of
questionnaires and interviews. This battery of tests will be repeated twice more over the
course of 6 months.
Selective spinal anesthesia is widely used for ambulatory surgery. Unilateral spinal
anesthesia is a suitable option for ambulatory anesthesia as it is efficient and effective.
Lidocaine has been the well-known choice for this procedure. However, it is associated to
transient neurologic symptoms (TNS). Different anesthetic strategies for this procedure have
been performed, for example, the use of small doses of long-acting agents and the use of
additives such as opioids. The ideal local anesthetic should be lidocaine-like without risk
of transient neurologic symptoms. We design and plan a randomised clinical trial to show if
hyperbaric prilocaine 2% would be an alternative.
The objective of this clinical study is to evaluate the influence of the Great
autohemotherapy with oxygen-ozone (hyperbaric ozone therapy ) to describe the cardiovascular
system in patients with resistant hypertension. The primary endpoint is the change in mean
blood pressure after 10 treatments .
In addition, data are collected on the immune system as well as for food and sleep quality.
Hypotension is extremely common after induction of spinal anesthesia for cesarean delivery.
Anesthetic blockade of the sympathetic outflow of the spinal cord causes vasodilation, and is
one cause of this hypotension. The higher the spread of the blockade will result in a higher
incidence of hypotension. Injected hyperbaric medication has about 15 minutes to spread
within the intrathecal space before it will be taken up by the nerve roots. The time that a
patient remains in one position after medication injection will affect the spread of the
resultant anesthetic block. A patient who is left sitting for a longer period of time after
injection of hyperbaric medication will have a lower level of block than someone who is
placed supine immediately. In this study, the investigators wish to use up down sequential
analysis to determine the time period a patient should remain seated after intrathecal
injection of hyperbaric bupivacaine and fentanyl that will result in a 50% rate of
hypotension.
The treatment for patients with acute tinnitus consists of Methylprednisolone and hyperbaric
oxygen therapy. For this study transcranial direct current stimulation (tDCS) was added to
the protocol. The purpose is to determine the effect of the time shift of tDCS. Two
conditions will be compared: tDCS simultaneously with the hyperbaric oxygen therapy or tDCS 3
weeks after the start of the tinnitus.
An audiological testing will be performed at the day of admission, after 3 weeks, 6 weeks and
12 weeks.
Cerebral radiation necrosis (CRN) is a well-documented late complication of radiation therapy
for cancers, and may have a devastating effect on the patient’s quality of life (QOL).
However,CRN was once regarded as a progressive and irreversible disease, no standard therapy
has been suggested for CRN. In our clinical practice, we have used
monosialotetrahexosylganglioside (GM1)to treat CRN, and found that GM1 can successfully
reverse CRN. So we carried out this prospective study to test the efficacy of GM1 for CRN.
The purpose of this study is to evaluate motor block probability throughout time and clinical
profile when using three different doses of HLBP 0.75% (7.5, 9.37 and 11.25 mg) by a
unilateral spinal block technique.
Spinal anesthesia, is used during the transuretheral resection of the prostate.Low dose
hyperbaric local anesthetics have been used to enhance the resolution of the spinal block. We
compared the efficacy and duration of the spinal block with two different bupivacaine
baricities.
Patients with brain metastases who are candidates for treatment with stereotactic
radiosurgery (SRS) are potential study participants. SRS delivers high-energy,
precisely-focused radiation to each brain metastasis to shrink the tumor, and is the
standard-of-care for patients with these tumors. Oxygen enhances the damaging effects of
radiation on tumor cells. Hyperbaric oxygen (HBO) therapy increases oxygen levels in all
kinds of tissues, including tumors. The purpose of this trial is to study whether it is
feasible to treat patients with HBO just prior to receiving SRS, given the timing constraints
of treating sequentially with HBO and then SRS. Patients will undergo HBO treatment followed
by the placement of a Gill-Thomas-Cosman head frame then transported ,via stretcher, to
receive SRS. The transfer and placement of the head frame needs to be completed within the
15minute time frame. The trial’s secondary objectives are to determine whether it has any
effects on outcomes and quality of life. As part of study participation patients will be
asked to complete quality of life questionnaires as well as mini mental status
questionnaires. These will be done prior to treatment and at follow up appointments
throughout the next 3 years while participating in the study. Patients will be given the
option to participate in the optional bio marker blood draw study which would require
patients to have blood drawn at three time points, pre-treatment, the day after treatment and
at their first follow up visit.
This study is designed to test the hypothesis that patients with Traumatic Brain Injury
(TBI)treated with Hyperbaric (HBO) will show improvement in function and an increased blood
flow as evidenced by single-photon emission computerized tomography (SPECT) scan. Improvement
is evidenced by increase in number of pixels on SPECT Scan and increased brain metabolism.
Improvement may also be identified via cognitive assessments administered by Jupiter Medical
Center Research Department.
