– Determine the effects of HBOT on burns conversion for patients who have fresh thermal
burns injury using the LDI.
– Objectively determine the proportion of burns conversion in areas of partial thickness
burns for early thermal burns injury in both arms of the RCT.
– Study the effects of HBOT on immunological markers IL-1, IL-2, IL-4, IL-6, IL-8, IL-10,
TNF-α and TGF-β ( comparison between both arms and 2 assessment points).
– Study the effect of HBOT on haematological markers including procalcitonin ,albumin,
lymphocyte counts, neutrophil count, and macrophage count.
– Study the effects of HBOT on histology specimens in quantifying P53 protein, leukocyte
and macrophage infiltration, burns depth assessment and vascular endothelial growth
factor (VEGF) and inducible nitric oxide synthase (iNOS) .
– Study the effects of HBOT on bacteriology of tissue culture in areas of deep dermal
burns.
The purpose of this study is to determine whether the hyperbaric oxygen treatment reduces
pain and improve the life quality in trigeminal neuralgia patients.
A prospective, Phase II, stratified, randomized study to compare the safety, ulcer healing,
patient compliance (concordance) and resource utilisation of a compression device with IPC
mode to a Class 3(c) UK standard graduated compression regime (4- layer system) on subjects
with venous leg ulcers.
Animal studies have shown that preconditioning with hyperbaric oxygen can induce central
nervous system and heart ischemic tolerance. This study was designed to determine the
protective effect of hyperbaric oxygen preconditioning on brain and myocardium
ischemia-reperfusion injury during coronary artery bypass graft surgery.
Several factors influence the extension of anesthetic mixture during spinal anesthesia
including anesthetic gravity, body position, drug volume, and drug-delivering velocity.
However, the effect of temperature of anesthetic mixture on the cephalad sensory blockade is
hitherto unknown. The investigators hypothesized that different temperatures of the
anesthetic mixture had different velocity of extension after spinal anesthesia. In addition,
previous studies suggest that parturients have relative higher sensitivity to temperature.
Herein the investigators proposed that the temperature of anesthetic mixture had more
extensive effect on the cephalad sensory blockade with spinal anesthesia for cesarean
delivery.
The purpose of this study is to determine if hyperbaric oxygen therapy (HBOT) improves the
cognitive function of OIF/OEF individuals who have chronic mild to moderate traumatic brain
injury (TBI). Cognitive function includes such things as thinking, remembering, recognition,
concentration ability and perception. Traumatic brain injury is common with head injuries
caused by blows to the head, nearby explosions, or concussion. Subjects will be assigned to
an intervention or sham arm. Computer based cognitive tests will be used as outcome measures.
Subjects are enrolled by invitation only.
To evaluate the levels of morphine in a patient’s blood when morphine is given into the
epidural space in the form of DepoDur® either alone or following a dose of lidocaine also
given in the epidural space.
There were evidences that the non-immune mediated inflammatory pathways of cell damage
occurred in vitro in human islets upon hyperglycemia in type 2 diabetes mellitus. Autologous
stem cell therapies were an emerging set of therapies that showed promise with a low side
effect profile. we hypothesized that infusion of mononuclear cells from buffy coat obtained
from bone marrow might provide multiple signals for regeneration and inflammation-induced
lesion recovery of local tissues, of which the effect might be maximized by intra-arterial
pancreatic infusion through angiography and combination with hyperbaric oxygen therapy.
This trail includes a foregoing sub-trial that investigate the feasibility and safety of a
novel method for massive bone marrow collection. The traditional BM collecting procedure is
unfavorable because it yields minor bone marrow. Studies have shown that physiological
exercise can increase bone marrow blood flow, which might facilitate BM collection.
We plan to include a total of 60 patients with type 2 diabetes and randomly assign them to
either a control group or an exercise group (n =30 each). The patients in the exercise group
exercised 30 minutes before the operation. All patients underwent routine surgical care. The
collected BM volume, operation time, collecting speed , puncture times and pain scores during
the operation were recorded. Bone marrow samples were tested for CD34+ flow cytometry and
whole blood cell count.
The objective is to define patient eligibility for hyperbaric oxygen therapy and to evaluate
wound healing progression using a new hyperspectral imaging technology.
There is currently not sufficient evidence that hyperbaric oxygen (HBO) benefits the surgical
removal of necrotic bone in osteoradionecrosis patients. This study aims at testing the
hypothesis that HBO does improve healing after surgical removal of necrotic bone in
irradiated previous head and neck cancer patients compared to not receiving HBO.
