This is a pilot trial to see if one or two 40 treatment courses of low pressure hyperbaric
oxygen therapy can improve cognition and brain imaging in subjects with either chronic
mild-moderate traumatic brain injury (TBI), also known as post-concussion syndrome (PCS) or
chronic PCS with post-traumatic stress disorder (PTSD) secondary to blast injury.
Clinical Trials
Clinical Trial – A Retrospective Analysis of Patients With Full Thickness Wounds in Limbs With Critical Ischemia
Once the patients are identified that have a full thickness wound on a limb clearly
identified as having critical limb ischemia, these patients will be evaluated. The data that
will be extracted from each chart will include patient’s age, patient’s gender, number of
office visits, presence of diabetes, presence of osteomyelitis, type and amount of antibiotic
administered, number of hyperbaric oxygen treatments, and if the wound healed.
Clinical Trial – The Effect of Hyperbaric Oxygen Therapy on Patients Suffering From Neurologic Deficiency Due Traumatic Brain Injury
Traumatic brain injuries (TBI) are a major cause of morbidity and mortality worldwide. Due to
improvements in emergency medical care, transportation and specialized trauma facilities, the
number of people surviving TBI with impairment has significantly increased in recent years.
The long term cognitive sequelae, which are often not visible persist far beyond the
resolution of the obvious physical disabilities. This combined with the relatively low
awareness of the general public has designated TBI as the "silent epidemic" (TBI CDC 2006).
Hyperbaric oxygen therapy (HBOT) has been suggested as a possible treatment modality for
these cases and preliminary studies are promising.
The purpose of this study is to evaluate the effectiveness of HBOT in the treatment of
chronic mild traumatic brain injuries (mTBI). Sequential SPECT scans of the brain and
neurocognitive testing will be used to evaluate cerebral blood flow (CBF) response, cognitive
and functional improvement following treatment.
Clinical Trial – Hyperbaric Oxygen Therapy Induced Neuroplasticity in Post Stroke Patients Suffering Chronic Neurological Deficiencies
The aim of the current work was to evaluate, for the first time in a prospective randomized
study, the effect of HBOT on patients with chronic neurological deficiency due to stroke.
Clinical Trial – Evaluation of a Medical Food for Chronic Wounds
The study objective is to compare outcomes in subjects with a diabetic foot ulcer after 16
weeks of consuming a medical food versus a calorically similar control drink.
Clinical Trial – Hyperbaric Oxygen for the Treatment of a Dry Mouth Which Occurred After Radiotherapy
The purpose of this study is to determine whether hyperbaric oxygen is effective in the
treatment of a dry mouth that occured after radiotherapy for head and neck tumours.
Clinical Trial – A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children
Autism is a developmental and behavioral pattern which includes the triad of impairments, 1.
social interaction 2. social communication 3. imagination. Inevitable difficulties in the
treatment, managing and handle with autistic children are the main problems. Their memories
are seemingly in picture or photo records, which are difference from normal population. There
are many concepts but no concise in causative factors, including useful treatments, useless
and prolong remaining in many studies.
HBOT (Hyperbaric Oxygen Therapy) is a quite modern treatment in Thailand for nitrogen
imbalance (decompression sickness syndrome or Caisson disease). How can we apply it to treat
the autism? A hypothesis shows evidence that neurons surrounding the permanently damaged
epicenter of injury can be reactivated with increased oxygen. Oxygen exists in the blood in
two forms, combined with hemoglobin and dissolved in plasma. More oxygen is transported by
hemoglobin, but oxygen is delivered to the tissues in dissolved form by the liquid portion of
blood. HBOT can increase in plasma oxygen to the tissues including the brain. A little change
in oxygen can make the better improvements in : cognitive ability, socialization, sleep,
calmness, decreased stimming and language. It can make increased in Glutathione (GSH), and
Glutathione (GSH) can decreased in oxidative stress with effected to remove metal compounds
(mercury) to improve the autism.
This clinical trial study divided into 3 group populations 1. general autism 2.
post-treatment chiropractic autism 3. medicated autism. This comparative study shows the
major clinical symptoms before and after the treatment with HBOT. This study results and
analysis are the most important for our further projects planning.
Clinical Trial – Effects of Hyperbaric Oxygen Therapy on Cognitive Function on Autistic Spectrum Disordered Children
HYPOTHESIS
1. Hyperbaric Oxygenation Therapy will be safe to use with neurotypical adults and
children.
2. Hyperbaric Oxygenation Therapy will have a statistically significant positive effect on
measures of cognitive function in neurotypical adults and children.
3. The improvement in cognitive function will correlate positively with the number of
Hyperbaric Oxygenation Therapy sessions.
4. Treatment gains obtained from Hyperbaric Oxygenation Therapy will be maintained at
follow-up, post 40 treatment sessions.
Clinical Trial – The Protective Effects Of Treatment With Hyperbaric Oxygen Prior To Bypass Heart Surgery
The purpose of this study was to determine if treating patients who have coronary heart
disease with hyperbaric oxygen (HBO) prior to coronary artery bypass graft (CABG) surgery
reduces injury to the heart and vascular system during and after surgery. Furthermore, this
study also aims to identify some of the post CABG clinical effects of HBO treatment prior to
CABG.
Clinical Trial – Hyperbaric Oxygen Therapy (HBOT) for Chronic Diabetic Lower Limb Ulcers
The purpose of this study is to determine if HBOT plus standard wound care is more effective
than standard wound care alone at preventing the need for major amputation (metatarsal and
up) in patients with diabetes mellitus (Type 1 or 2) with moderate to sever chronic wounds of
lower limbs.