Veterans Special Report
HBOT Research

Clinical Trial – Effect of Self-acupressure on Middle Ear Barotrauma Associated With Hyperbaric Oxygen Therapy

Mar 16, 2020 | , ,

Middle ear barotrauma (MEB) is the most common complication during hyperbaric oxygen therapy
(HBOT). Though Valsalva and Toynbee maneuvers have been proposed to prevent MEB, still some
patients discontinue HBOT due to severe otalgia, hemorrhage or perforation of tympanic
membrane associated with HBOT. Currently, there is no optimal prophylactic management for MEB
associated with HBOT. The aim of this protocol is to investigate the efficacy of
self-acupressure therapy on MEB associated with HBOT.

Clinical Trial – Hyperbaric Oxygenation in Athletes: Standard Versus Low Pressure

Mar 4, 2020 | , ,

Currently, Hyperbaric Oxigen (HBO) is a widely used treatment for several conditions. There
are 14 indications for HBO, officially recognized by the Undersea and Hyperbaric Medical
Society (UHMS), but research is discovering other interesting applications.

HBO plays an important role in enhancing antioxidant defense mechanisms by increasing radical
oxygen species (ROS) and nitric oxide species (NOS). This controlled oxidative stress has
been shown to stop the vicious circle of inflammation – damage – hypoxia already seen in
several diseases. Increased neoangiogenesis has been demonstrated at pressures of 2
atmospheres absolute (ATA), while effects helping ischemic tissues need pressures between 2.5
and 2.8 ATA to develop.

During sports activities, metabolism generates waste products – mostly CO2, lactic acid, but
also ROS. HBO could be useful in modulating antioxidant mechanisms and helping cells in the
recovery after training and sportive competitions.

The authors hypothesize that:

1. HBO can reduce oxidative stress in healthy professional athletes

2. HBO can ameliorate the lactic acid clearance after a maximal exercise

3. HBO at low pressures (L-HBO at 1.45 ATA) is at least comparable to conventional HBO (at
2.5 ATA) in reducing oxidative stress and ameliorating lactic acid clearance after a
maximal exercise.

The Authors will include healthy athletes. These will be randomly assigned to a control
group, a L-HBO group, or a HBO group. The Authors will assess oxidative stress changes and
lactic acid clearance (testing it after a maximal exercise) before and after 20 L-HBO/HBO
treatments, and after 2 months after the end of treatments.

Clinical Trial – Hyperbaric Oxygen Therapy Compared to Pharmaceutical in Fibromyalgia With Emotional Trauma

Mar 3, 2020 | , ,

The investigators have previously studied the efficacy of hyperbaric oxygen therapy (HBOT) as
a treatment for Fibromyalgia syndrome (FMS) in a prospective, active control, crossover
clinical trial. The results demonstrated significant amelioration of all FMS symptoms, with
significant improvement in life quality; furthermore, the investigators were able to
demonstrate significant neuroplasticity on SPECT imaging, with a decrease of the
hyperactivity in posterior regions and elevation of the reduced activity in frontal areas.

In this study, the investigators intend to both repeat and expand the investigator’s previous
findings, treating FMS patients with history of emotional trauma with HBOT, while performing
an extensive of evaluation both before and after treatment.

In the current study, the investigators plan to compare HBOT to current standard of care of
FMS (pharmacological and non – pharmacological).

Clinical Trial – The Effects of Ilioinguinal Nerve Block on Chronic Pain in Patients in Inguinal Hernia With Spinal Anesthesia

Feb 29, 2020 | , ,

Regional anesthesia is a popular anesthetic method in patients who will undergo an inguinal
hernia operation. Researchers known that pain in the operating area is a complaint that
impairs the quality of life for patients in the long term after the operation. In addition to
regional anesthesia, has planned to investigate the effects of applying another drug near the
surgery area on pain that may develop in the long term.

Clinical Trial – Cognitive Profile of Patients at the Sagol Center for Hyperbaric Medicine and Research

Feb 25, 2020 | , ,

In the investigator’s institute there is ongoing treatment of different patients with
cognitive deficits using Hyperbaric oxygen therapy (HBOT). These patients undergo
neuro-cognitive function computerized tests before and after treatment.

The aim of this study was to retrospectively evaluate the cognitive changes before and after
HBOT in different patients populations.

Clinical Trial – Postoperative Urinary Retention in Orthopedic Patients

Feb 14, 2020 | , ,

The objective of this study is to compare the incidence of postoperative urinary retention
related to spinal anesthesia with morphine and spinal anesthesia associated with peripheral
blockade in orthopedic procedures of lower limbs. Secondary objectives are assessing the
incidence of nausea and vomiting; postoperative pain and opioid consumption at 24 hours after
surgery with each of the techniques. A total of 52 patients submitted to a lower limb
orthopedic procedure were randomized to the intervention groups: spinal anesthesia with
morphine versus spinal anesthesia without opioid associated with peripheral nerve block.
After surgery, bladder ultrasound will be performed in post-anesthesia care unit to identify
urinary retention and patients will be followed for 24 hours to assess outcomes.

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