Subjects with Acute Myeloblastic Leukemia (AML) and myelodysplastic syndrome (MDS) who are
considered eligible for allogeneic stem cell transplant by the transplant team at WCI (Wilmot
Cancer Institute)will be enrolled in the study. Patients will receive Melphalan on day -2 and
HBO (Hyperbaric Oxygen) therapy on day 0 of the transplant. After neutrophil recovery is
documented, the patients will be seen in clinic at least weekly through day +100.
HBOT Research
Clinical Trial – Effect of Hyperbaric Oxygen Therapy on Microcirculation
Previous studies shoes that hyperoxia alters microcirculation.The investigators hypothesize
that hyperbaric may restore microcirculation integrity. This hypothesis is supported by a
recent study in rabbits, but no data exists for humans.
The study will expose fifteen healthy volunteers to a succession of different fraction of
inspired oxygen and barometric pressure and assess microcirculatory and macrocirculatory
changes via sidestream dark field videomicroscopy, near-infrared spectroscopy, Laser Doppler,
transthoracic echocardiography and bio-impedancemetry at every step.
Clinical Trial – 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
Spinal anesthesia is commonly utilized for hip replacement surgery. Different medications
used for spinal anesthesia work for different lengths of time. This study will compare three
different spinal anesthesia medications in patients having hip replacement surgery to see if
patients are able to get out of bed and walk earlier after surgery with one medication versus
the others.
Clinical Trial – Comparision of Different Doses of Dexmedetomidine With Low Dose Bupivacaine in Selective Spinal Anesthesia.
The charactereistics of a spinal block varies with the dose of local anaesthetic and the
adjuvant used. Literature review did not show comparison of different doses of
dexmedetomidine with low-dose bupivacaine in saddle block. The rationale of this study is to
determine an optimum dose of dexmedetomidine which in combination with low dose bupivacaine
would provide satisfactory block with hemodynamic stability. This would be beneficial for
patients scheduled for turp, as these pts are mostly elderly with various comorbidities.
Clinical Trial – Intrathecal Atropine vs IV Metoclopramide for Nausea & Vomiting During CS
The aim of this study is to evaluate the prophylactic use of low dose atropine and comparing
it to metoclopramide for reducing intraoperative nausea and vomiting during cesarean section
under spinal anesthesia
Clinical Trial – Carbon Monoxide-induced Coma: Prognostic Factors
The primary objective of the study is to determine prognostic factors for ICU-mortality
following carbon monoxide (CO)-induced coma. The secondary objective is to determine
prognostic factors of CO related cognitive sequelae, at the time of intensive care unit (ICU)
discharge.
Clinical Trial – Intrathecal Nalbuphine Versus Midazolam in Cesarean Section
Adequate pain management is important to facilitate the functional recovery and enable the
patients for rapid rehabilitation of normal activity .
Various adjuvants were being used with intrathecal bupivacain to prolong & improve
postoperative pain relief in patients undergoing cesarean section .
The aim of this study was to compare intrathecal nalbuphine versus intrathecal midazolam in
patient undergoing cesarean section. The investigators primary aims were to compare the
characteristics of sensory and motor block, the effective analgesic time, and analgesic
requirement. Secondary aims were to compare the side effects, sedation score and apgare
score.
Clinical Trial – Acute Post-Radiation Hyperbaric Oxygen (HBO2) for Breast Cancer Patients Who Have Recently Completed Radiation Therapy
This study aims to compare patients that receive hyperbaric oxygen or Trental and Vitamin E
immediately after completion of radiation therapy to evaluate which treatment best reduces
radiation fibrosis.
The National Brain Injury Rescue and Rehabilitation Study – a multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms
The National Brain Injury Rescue and Rehabilitation Project was established as a preliminary study to test the safety and practicality of multi-center hyperbaric oxygen administration for the post-concussive symptoms of chronic mild traumatic brain injury as a precursor to a pivotal, independent, multi-center, controlled clinical trial. This report presents the results for 32 subjects who completed a preliminary trial of hyperbaric oxygen several years before the passage of the 21 st Century Cures Act. This study anticipated the Act and its reassessment of clinical research. Subjects received 40-82 one-hour treatments at 1.5 atmospheres absolute 100% oxygen. Outcome measures included repeated self-assessment measures and automated neurocognitive tests. The subjects demonstrated improvement in 21 of 25 neurocognitive test measures observed. The objective neurocognitive test components showed improvement in 13 of 17 measures. Earlier administration of hyperbaric oxygen post injury, younger age at the time of injury and hyperbaric oxygen administration, military status, and increased number of hyperbaric oxygen administrations were characteristics associated with improved outcomes. There were no adverse events. Hyperbaric oxygen was found to be safe, inexpensive and worthy of clinical application in the 21 st Century model of facile data collection provided by recent research regulatory shifts in medicine. The study was approved by the ethics review committee of the Western Institutional Review Board (WIRB; Protocol #20090761).
Growth Hormone Deficiency: Health and Longevity
Abstract The important role of GH in the control of mammalian longevity was first deduced from extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with isolated GHD (IGHD) due to GHRH or GHRH receptor mutations, combined deficiency of...