Abstract: To examine visual acuity, refraction and ocular status before, during and after hyperbaric oxygen therapy (HBOT). Twenty-nine patients underwent 40 standard protocol HBOT treatments. In all subjects, refraction and best corrected visual acuity were measured...
HBOT Research
Medical thoracoscopy removal of a self-expandable metallic stent migration into pleural cavity.
Abstract: Pleuroscopy, also known as medical thoracoscopy (MT), is an important tool for pleural disease management. Removal of foreign body (FB) by MT was reported in a few reports because it can identify the position of a FB in the pleural cavity and can be used for...
Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery.
Abstract: Brain radionecrosis (tissue death caused by radiation) can occur following high-dose radiotherapy to brain tissue and can have a significant impact on a person's quality of life (QoL) and function. The underlying pathophysiological mechanism remains unclear...
Hyperbaric Oxygen Therapy in Ischaemic Foot Ulcers in Type 2 Diabetes: A Clinical Trial.
Several treatment modalities and protocols for ischaemic foot ulcers are available. However, little consensus exists on optimal treatment. The aim of this study was to compare Standard Wound Care (SWC) alone SWC with adjunct hyperbaric oxygen therapy (HBOT) in the treatment of ischaemic Diabetic Foot Ulcers (DFUs). Twenty-six patients with Type 2 Diabetes Mellitus (T2DM) presenting with a newly diagnosed ischaemic foot ulcer were included. These were divided into group A (SWC with adjunct HBOT) and group B (SWC only). Participants were followed every week for 4 weeks and their ulcers were measured for their surface area and depth to assess any change in wound size. Both treatment arms succeeded in reducing ulcer area and depth (p<0.001).
Clinical Trial – Short Duration Hyperbaric Oxygen Therapy to Improve HbA1c, Leukocyte, and Serum Creatinine
The investigators want to evaluate the short duration HBOT can improve glycohemoglobin
(HbA1c) levels, leukocyte count, and serum creatinine levels in patients with DFU (diabetic
foot ulcer) Wagner 3-4.
ECMO improves survival following cardiogenic shock due to carbon monoxide poisoning – an experimental porcine model.
Abstract: Severe intoxication with carbon monoxide (CO) is extremely lethal and causes numerous deaths due to cardiac or respiratory failure. Conventional intensive treatment may not be sufficient. The aim of this study was to investigate the treatment effect of...
Clinical trials targeting hypoxia.
Abstract: The concept of tumour hypoxia as a cause of radiation resistance has been prevalent for over 100 years. During this time, our understanding of tumour hypoxia has matured with the recognition that oxygen tension within a tumour is influenced by both diffusion...
Early Hyperbaric Oxygen Treatment Attenuates Burn-Induced Neuroinflammation by Inhibiting the Galectin-3-Dependent Toll-Like Receptor-4 Pathway in a Rat Model.
Abstract: Hyperbaric oxygen (HBO) treatment has been proven to decrease neuroinflammation in rats. This study aimed to determine the potential mechanism underlying the anti-inflammatory effects of HBO treatment on burn-induced neuroinflammation in rats. Thirty-six...
Clinical Trial – Correlation Between VCL, AC and Spread of Intrathecal Hyperbaric Bupivacaine in the Term Parturient
Currently there is no guideline to decide on the most appropriate dose of spinal anaesthesia.
This study is planned to find out factors that influence the effect of spinal anaesthesia in
pregnant mother going for Caesarean section and both the mother and baby’s outcomes.
Investigators will recruit pregnant mothers who are planned for elective Caesarean section
under spinal anaesthesia at University Malaya Medical Centre before operation and obtained
their consent to participate in this study. Routine standard care will be provided for all
the participants. Perioperative data including vertebral column length and abdominal girth
measured by measuring tape will be collected and analysed. There is no new intervention
performed on participants.
Variability in Treatment for Carbon Monoxide Poisoning in Japan: A Multicenter Retrospective Survey.
Abstract: The aim of this study was to identify practice differences in the treatment of carbon monoxide (CO) poisoning with or without hyperbaric oxygen (HBO) therapy in Japan. Using an online survey website (Google form), we created a questionnaire and invited...