Ischemic stroke is a devastating and debilitating medical condition with limited therapeutic options. However, accumulating evidence indicates a central role of inflammation in all aspects of stroke including its initiation, the progression of injury, and recovery or wound healing. A central target of inflammation is disruption of the blood brain barrier or neurovascular unit. Here we discuss recent developments in identifying potential molecular targets and immunomodulatory approaches to preserve or protect barrier function and limit infarct damage and functional impairment.
HBOT Research
Clinical Trial – Nalbuphine Versus Fentanyl As Additives To Bupivacaine In Spinal Anaesthesia For Internal FixationI Of Tibia
The Efficacy Of Nalbuphine Versus Fentanyl As Additives To Bupivacaine In Spinal Anaesthesia
For Internal FixationI Of Tibia
Early Effects of Hyperbaric Oxygen on Inducible Nitric Oxide Synthase Activity/Expression in Lymphocytes of Type 1 Diabetes Patients: A Prospective Pilot Study.
This study aimed at examining the early effects of hyperbaric oxygen therapy (HBOT) on inducible nitric oxide synthase (iNOS) activity/expression in lymphocytes of type 1 diabetes mellitus (T1DM) patients. A group of 19 patients (mean age: 63 ± 2.1) with T1DM and with the peripheral arterial disease were included in this study. Patients were exposed to 10 sessions of HBOT in the duration of 1 h to 100% oxygen inhalation at 2.4 ATA. Blood samples were collected for the plasma C-reactive protein (CRP), plasma free fatty acid (FFA), serum nitrite/nitrate, and serum arginase activity measurements. Expression of iNOS and phosphorylation of p65 subunit of nuclear factor-B (NFB-p65), extracellular-regulated kinases 1/2 (ERK1/2), and protein kinase B (Akt) were examined in lymphocyte lysates by Western blot.
Nontoxic Targeting of Energy Metabolism in Preclinical VM-M3 Experimental Glioblastoma.
Abstract: Temozolomide (TMZ) is part of the standard of care for treating glioblastoma multiforme (GBM), an aggressive primary brain tumor. New approaches are needed to enhance therapeutic efficacy and reduce toxicity. GBM tumor cells are dependent on glucose and...
Orbitomaxillofacial Mucormycosis Requiring Complex Multifactorial Management.
Abstract: Mucormycosis is a rare fungal infection caused by ubiquitous fungi in the order Mucorales. It is the most rapidly progressing fulminant fungal infection that mimics necrotizing soft-tissue infections. Overwhelming fungal sepsis develops quickly and mortality...
Massive air embolism as a complication of upper gastrointestinal endoscopy: A case report illustrating a stroke mimic, literature review, and suggested management.
Abstract: Cerebral air embolism should be considered in case of stroke symptoms during any invasive procedure. Transport to a hospital with neurosurgical/hyperbaric oxygen treatment (HBOT) facility could improve the outcome for the patient. Absence of air on computed...
The Effect of Hyperbaric Oxygen Therapy on Functional Impairments Caused by Ischemic Stroke.
While research suggests a benefit of hyperbaric oxygen therapy (HBOT) for neurologic injury, controlled clinical trials have not been able to clearly define the benefits. To investigate the effects of HBOT on physical and cognitive impairments resulting from an ischemic stroke. Using a within-subject design a baseline for current functional abilities was established over a 3-month period for all subjects (n=7). Each subject then received two 4-week periods of HBOT for a total of 40 90-minute treatments over a 12-week period. Subjects completed a battery of assessments and had blood drawn six times over the 9-month total duration of the study.
Clinical Trial – Hyperbaric Oxygenation Treatment and Quality of Life
Osteoradionecrosis, dermal soft tissue necrosis, radiation cystitis, proctitis and sexual
dysfunctions are well-known late-effects after radiation for cancer in the pelvic area,
negatively affecting the survivors’ quality of life (QOL) and psychosocial wellbeing.
Increasing evidence and clinical practice support the use of hyperbaric oxygen treatment
(HBOT) as an effective treatment in a variety of radiation injuries, but this is still a
field with limited research and knowledge. Especially, there is a knowledge gap on how late
radiation tissue injury (LRTI) influences cancer survivors’ QOL and psychosocial health in a
longitudinal perspective (before, along and after HBOT), as well as the patients’ knowledge,
expectation and experience from this treatment. This study aims to improve knowledge on these
issues.
Carinal surgery: A single-institution experience spanning 2 decades.
Abstract: Complete resection of neoplasms involving the carina are technically challenging and have high operative morbidity and mortality. This study examines the last 2 decades of clinical experience at our institution. Medical records were retrospectively reviewed...
Clinical Trial – The Effect of Hyperbaric Oxygen Therapy on Aerobic and Anaerobic Physical Fitness
Previous evidence showed hyperbaric oxygen can enhance aerobic and anaerobic performance
during the exposure. The effect of continuous exposure of hyperbaric oxygen on performance
was never evaluated.