Abstract: Uremic encephalopathy (UE), a toxic metabolic encephalopathy, is an uncommon complication resulting from endogenous uremic toxins in patients with severe renal failure. UE syndrome can range from mild inattention to coma. The imaging findings of UE include...
HBOT Research
Clinical Trial – Spinal Hydromorphone Versus Morphine for Post-Cesarean Delivery Analgesia
Morphine is usually used for pain relief after cesarean delivery. However, sometimes it is
not available, the patient might be allergic to morphine or intolerant to its side effects.
Hydromorphone, another drug from the same class, might be used alternatively, but we need to
prove that it is not inferior to morphine.
The effectiveness of hyperbaric oxygen therapy for healing chronic venous leg ulcers: a randomized, double-blind, placebo-controlled trial.
Abstract: Over 30% of venous leg ulcers do not heal despite evidence-based treatment. This study aimed to determine the effectiveness of Hyperbaric Oxygen Therapy (HBOT) as an adjunct treatment for nonhealing venous leg ulcers. A randomized, double-blind, parallel...
The effectiveness of hyperbaric oxygen therapy for healing chronic venous leg ulcers: A randomized, double-blind, placebo-controlled trial.
Abstract: Over 30% of venous leg ulcers do not heal despite evidence-based treatment. This study aimed to determine the effectiveness of Hyperbaric Oxygen Therapy (HBOT) as an adjunct treatment for nonhealing venous leg ulcers. A randomized, double-blind, parallel...
Synergistic effect of hyperbaric oxygen therapy with PTH [1-34] on calvarial bone graft in irradiated rat.
Abstract: To determine the synergistic effect of parathyroid hormone (PTH) [1-34] in combination with hyperbaric oxygen (HBO) on bone graft in a rat calvarial bone defect model under impaired osteogenic conditions. Twenty-four rats were divided into three groups....
Hyperbaric Oxygen Therapy for Alzheimer’s Disease.
Recent studies indicate that hyperbaric oxygen therapy (HBOT), a well-established therapy for decompression illness, could be a potential therapy for Alzheimer’s disease (AD). However, due to oxygen toxicity i.e., increased oxidative stress implicated in HBOT, the risk and benefit of HBOT for AD patients need to be further assessed clinically.
Modelling of ciprofloxacin killing enhanced by hyperbaric oxygen treatment in Pseudomonas aeruginosa PAO1 biofilms.
Abstract: In chronic lung infections by Pseudomonas aeruginosa (PA) the bacteria thrive in biofilm structures protected from the immune system of the host and from antibiotic treatment. Increasing evidence suggests that the susceptibility of the bacteria to antibiotic...
Clinical Trial – Effect of Different Types of Anesthesia on Perioperative Brain Natriuretic Peptide Levels in Parturient Cardiac Patient Undergoing Elective Cesarean Section
comparing the effect of general anesthesia versus spinal anesthesia on brain natruretic
peptide hormone levels preoperatively and postoperatively in parturient cardiac patient
undergoing cesarean section
Clinical Trial – Hyperbaric Oxygen Therapy for Adult Onset Post Traumatic Stress Disorder
Posttraumatic stress disorder (PTSD) is the long term effect of severely distressing
traumatic event characterized by intrusive thoughts, nightmares, and avoidance. Brain imaging
of PTSD patients demonstrate alterations in regional brain perfusion, with stunned,
hypoperfused regions. Those brain-biological pathologies may be responsible for the limited
success rate of currently available interventions.
During the last years data regarding Hyperbaric Oxygen Therapy (HBOT) induced neuroplasticity
accumulated. A number of studies in traumatic brain injury, cerebrovascular attacks, and
fibromyalgia have presented evidence of improved perfusion and recovery of metabolic brain
tissues, accompanied by clinical improvement under HBOT even years after the acute insults.
Considerable evidence supports potential benefit of HBOT on PTSD, however, no clinical trial
was done on this pure PTSD population. The aim of the proposed study is to examine hyperbaric
oxygen therapy as a treatment for PTSD. Advanced brain imaging and functional analysis tools
will be used to evaluate treatment’s effect.
Ulcerated Necrobiosis Lipoidica.
A 23-year-old Caucasian female, with type I diabetes mellitus, presented with a 7-month history of two painful yellowish-red plaques with ulcerated centre in the left leg. A diagnosis of ulcerated necrobiosis lipoidica (NL) was made and she was started on pentoxifylline 400 mg tid and tacrolimus ointment 0.1%. After four months of treatment with no improvement, the patient was proposed for hyperbaric oxygen therapy (HBOT). Overall, she received a total of 30 sessions of HBOT, after which the wounds healed completely. There have been no recurrences in the 14 months following resolution.