Patients with Multiple Myeloma who are considered for high-dose therapy and autologous
transplantation at the bone marrow transplant clinic at the Wilmot Cancer Institute (WCI)
will be be approached to participate in this trial. Eligible patients who choose to
participate will be randomized so that half receive one hyperbaric oxygen therapy session
prior to hematopoetic stem cell infusion and half will not. All subjects will have their
blood counts monitored closely and time to count recovery will be compared between the two
groups.
HBOT Research
Experiences of family caregivers the first six months after patient diagnosis of necrotising soft tissue infection: A thematic analysis.
Abstract: Necrotising soft tissue infection, or necrotising fasciitis, is a rapidly progressing disease requiring immediate diagnosis and treatment consisting of antimicrobial therapy, hyperbaric oxygen, debridement surgery and treatment in the intensive care unit....
Hyperbaric Oxygen Therapy in Liver Diseases
Abstract: Hyperbaric oxygen therapy (HBOT) is an efficient therapeutic option to improve progress of lots of diseases especially hypoxia-related injuries, and has been clinically established as a wide-used therapy for patients with carbon monoxide poisoning,...
Hyperbaric Oxygen Therapy in Liver Diseases.
Abstract: Hyperbaric oxygen therapy (HBOT) is an efficient therapeutic option to improve progress of lots of diseases especially hypoxia-related injuries, and has been clinically established as a wide-used therapy for patients with carbon monoxide poisoning,...
Clinical Trial – Decompression Tables for Diving at Altitude
The aims of this proposal are to test current USN procedures for adjusting decompression
procedures during air diving at 8,000 and 10,000 ft altitude and to provide a decompression
algorithm for no-stop dives to 100 feet of sea water (fsw) at 10,000 and 12,000 ft altitude
using enriched O2 (PO2=1.3 ATM). Additionally, the experiments will determine whether a
period of hyperbaric hyperoxia, such as would be experienced during a dive at altitude,
reverses altitude acclimatization, resulting in a return of acute mountain sickness (AMS)
symptoms.
Hyperbaric oxygen therapy as an adjuvant to source control in necrotizing soft tissue infections.
Abstract: Necrotizing soft tissue infections (NSTI) are rare but potentially lethal disorders, and adequate management is time- and resource-demanding. This study aims to assess whether variations in the treatment modalities - surgery, hyperbaric oxygen (HBO₂) therapy...
The protection effect and mechanism of hyperbaric oxygen therapy in rat brain with traumatic injury.
To investigate the effect of hyperbaric oxygen therapy (HBOT) on traumatic brain injury (TBI) outcome. The modified Marmarou’s weight drop device was used to generate non-lethal moderate TBI rat model, and further developed in vitro astrocytes culturing system. Then, we analyzed the expression changes of interested genes and protein by quantitative PCR and western blot. Multiple HBO treatments significantly reduced the expression of apoptosis promoting genes, such as c-fos, c-jun, Bax and weakened the activation of Caspase-3 in model rats. On the contrary, HBOT alleviated the decrease of anti-apoptosis gene Bcl-2 and promoted the expression of neurotrophic factors (NTFs), such as NGF, BDNF, GDNF and NT-3 in vivo. As a consequent, the neuropathogenesis was remarkably relied with HBOT.
Clinical Trial – Sequential Intrathecal Injection of Fentanyl and Hyperbaric Bupivacaine
56 Parturients, aged 18-40 year, undergoing elective CS were randomly assigned to receive
sequential intrathecal injection of fentanyl and hyperbaric bupivacaine at the same rate
(normal sequential) NS or a rapid intrathecal injection of fentanyl followed by slow
injection of hyperbaric bupivacaine (rapid sequential) RS. Time of first rescue analgesia,
Dose of rescue analgesics, degree of postoperative pain, incidence of hypotension,
hypotension duration, ephedrine dose, spinal anaesthesia related complications and failed
block were recorded.
Clinical Trial – Prilocaine or Bupivacaine for Spinal Anesthesiain Pregnant
The planned cesarean section is an intervention with a standard operating time of less than
40 minutes in trained teams. Hyperbaric Bupivacaine is the local anesthetic (LA) reference
for these operations. But the duration of its motor block is generally greater than 3 hours.
The purpose of this study is to show a reduction in motor block time with hyperbaric
Prilocaine by at least 30 minutes, which would allow mothers and their children to return to
the maternity ward earlier and thus improve the circulation of patients within the
maternity’s PACU.
Femoral condylar necrosis: treatment with hyperbaric oxygen therapy.
Abstract: Osteonecrosis of the knee (ONK) is a form of aseptic necrosis resulting from ischemia to subchondral bone tissue. Typically, treatment is invasive. Hyperbaric oxygen therapy (HBOT) may provide a noninvasive alternative by improving oxygenation and...