A prospective, randomized investigation with appropriate power would determine whether or not
postoperative hyperbaric oxygen therapy improves wound healing in patients with soft tissue
sarcoma undergoing surgical resection with neo-adjuvant radiation therapy.
HBOT Research
Clinical Trial – Hyperbaric Oxygen Therapy for Inflammatory Conditions of the Urinary Bladder
Pilot study to determine feasibility for treating patients with two chronic inflammatory
conditions of the urinary bladder: chronic interstitial cystitis and recurrent urinary tract
infections using a standardized hyperbaric oxygen treatment plan. Presently there are no good
treatments for these conditions and hyperbaric oxygen may be a safe and readily accessible
therapy as it has proven successful an another type of chronic inflammatory condition of the
urinary bladder known as "radiation cystitis". The study will determine if patients will
consider this an acceptable treatment for their conditions and that it is well tolerated.
Clinical Trial – Insulin Sensitivity During Hyperbaric Oxygen Compared to Hyperbaric Air
In a recent series of studies performed by our group, we have shown that exposure to
hyperbaric oxygen (HBO) leads to an increase in insulin sensitivity in male subjects with
type-2 diabetes (T2DM) and in obese and overweight men without diabetes. The aim of this
study is to investigate the relationship between pressure and oxygen in producing this
effect, specifically, is this effect measurable in hyperbaric air or is some higher pressure
of oxygen required?
Aims:
1. To determine whether the insulin sensitising effect of HBO is apparent in hyperbaric air
at the same pressure as HBO.
2. To examine mechanisms underpinning the increase in insulin sensitivity following HBO.
Clinical Trial – GA/Spinal vs. GA/Spinal/NMB for Operative Repair of Hip Fracture
Surgical repair of hip fractures may be performed with various anesthetic techniques, but are
most commonly completed under general anesthesia (GA) or neuraxial anesthesia (NA). Numerous
prospective and retrospective studies demonstrate improved morbidity and mortality when NA is
used; however, many surgeons prefer the use of GA with neuromuscular blockade (NMB) due to
the perception of better operative conditions. This study aims to compare the operative
conditions obtained from the use of combined GA and spinal with NMB vs. the use of GA with
spinal without NMB. 84 patients will all receive a single shot spinal and GA and then will be
randomized to receive either NMB or placebo. The fracture reduction time will be measured.
Concussion Help in a Hyperbaric Chamber? Local Doctor Says Treatment Can Get Rid of Injury
HBOT for Conussions. An old and familiar piece of technology is being used in the northern suburbs for a whole new reason: to get rid of concussions. Chicago-area doctor Daphne Denham says, when it comes to acute concussions, typically those that have occurred in 10...
A Prospective, Randomized, Blinded, Controlled Trial Comparing Transdermal Continuous Oxygen Delivery to Moist Wound Therapy for the Treatment of Diabetic Foot Ulcers.
Abstract: Worldwide, diabetic foot ulcers (DFUs) continue to exact a major burden on patients and health care providers. Although hyperbaric oxygen therapy is well-known as an adjunct option, less is known about the efficacy of transdermal continuous oxygen therapy...
Effect of hyperbaric air on endotoxin from Bacteroides fragilis strains.
Abstract: The aim of the project was to determine any effect of hyperbaric air on Bacteroides fragilis strains cultivated under hyperbaric conditions. Previously, it was hypothesized that there was a correlation between the presence of Bacteroides bacteria in patients...
Clinical Trial – Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study
The investigators will analyze biomarkers related to the prognosis and treatment of
necrotizing soft tissue infections (NSTI). The focus will be on whether certain endothelial
and immune system biomarkers can function as markers of disease severity, mortality as well
as the effects of hyperbaric oxygen therapy (HBOT). Biomarkers will be measured upon
admission to an intensive care unit at Copenhagen University Hospital and during the
following 3 days.
Relationship between hyperbaric oxygen therapy and quality of life in participants with chronic diabetic foot ulcers: data from a randomized controlled trial.
Abstract: To investigate the effect of hyperbaric oxygen therapy on health-related quality of life (HRQoL) in participants with diabetes and chronic foot ulcers. Using data from a randomized controlled trial, we included 103 participants (49 in hyperbaric oxygen...
Hyperbaric oxygen for experimental intracerebral haemorrhage: Systematic review and stratified meta-analysis.
Abstract: Hyperbaric oxygen (HBO) is widely used in treating various neurological diseases. However, HBO for treatment of intracerebral haemorrhage (ICH) remains controversial, in either animal or clinical studies. Therefore, we conducted this systematic review and...