Veterans Special Report
Local

Clinical Trial – ED50 and ED95 of Isobaric Bupivacaine for Post-Partum Bilateral Tubal Ligation

Dec 17, 2018 | , , ,

Spinal anesthesia is one of the preferred anesthetic techniques for post-partum bilateral
tubal ligation (PBTL). Bupivacaine is the most commonly used local anesthetic for neuraxial
anesthesia for post-partum tubal ligation. Typically, hyperbaric bupivacaine would be
injected into the spinal (intrathecal) space via a spinal needle; however, ongoing medication
shortages have resulted in limited availability on a local and national level. One proposed
alternative is isobaric bupivacaine; however, studies investigating its use for post-partum
bilateral tubal ligation are limited.

The purpose of this prospective study is to determine the minimal effective dose (ED50 and
ED95) of isobaric bupivacaine for adequate anesthesia during post-partum tubal ligation after
vaginal delivery.

Clinical Trial – Heavy Bupivacaine in Peribulbar Block

Oct 13, 2017 | , , ,

Most of the ophthalmic procedures are performed under local anesthesia as the patient is
often elderly and with diseases. This may increase the risk of morbidity and mortality under
general anesthesia. Different eye blocks have been practiced with great success. Moreover, it
is associated with less hemodynamic instability, less respiratory depression, better
postoperative pain relief, and less nausea and vomiting than general anesthesia. It is also
associated with a reduction in stress response, maintained oxygen saturation and
cardiovascular stability, in addition to the production of good akinesia and anesthesia
alleviating occulo-medullary reflexes, all make local anesthesia more superior and safe
technique.

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