This is a pilot study of radiotherapy using Hypofractionated image – guided helical
tomotherapy after hyperbaric oxygen HBO therapy for treatment of recurrent malignant
High-grade gliomas. HBO therapy will be perform in conjunction with each RT session.

The treatment scheme is:

Hyperbaric oxygenation therapy (the maximum period of time from completion of decompression
to RT is 60 min) followed by tomotherapy (3-5 consecutive sessions- one fraction per day , 5
Gy / die ).

The trial will enroll 24 patients in 24 months with a follow-up period of 1 year.