The Effects of Colloid Pre-Loading on D-Dimer of the Mother and Her Baby During Cesarean Section Under Spinal Anesthesia for Mild Preeclampsia
Description:
The patients were divided into two equal group of thirty patients in each group; Control
group (normotensive pregnant women) and Mild preeclampsia group. In both groups patients
preloaded with 500 mL hydroxyethyl starch (HES) 6% (130/0.4) (Voluven). Spinal anesthesia
will be performed with intrathecal 10-12 mg hyperbaric bupivacaine in addition to 200 meg
morphine. The patient was placed supine with left lateral tilt to alleviate aortocaval
compression. 10 ml/kg of isotonic 0.9 sodium chloride (NaCl) solutions will be used co
loading during the duration of the operation. Blood pressure was measured and recorded every
three minutes. If severe hypotension (fall of > 20% of mean arterial pressure from baseline)
occurred, vasopressors, 6 mg ephedrine (per dose) will be used. The blood pressure will
rechecked 1 minute after each doses of ephedrine. If hypotension persisted after 30 mg of
ephedrine, an additional 2 ml/kg of isotonic 0.9 NaCl solutions will be infused rapidly.
Maternal hypotension is defined as at least a single administration of ephedrine within the
period from induction of spinal anesthesia until transfer to postoperative recovery unit.
Reactive hypertension is characterized as a blood pressure 20% greater than baseline mean
levels after the use of the vasopressor. Bradycardia is defined as a fall of >30% of heart
rate from baseline or <50 beats /minute. Bradycardia, and when associated with hypotension it
will be treated with 0.5 mg of atropine intravenous. Upon completion of the cesarean section,
the subject will be transported to the postanesthesia care unit (PACU).
Condition:
Coagulation Defect; Bleeding
Treatment:
hydroxyethyl starch (6% 130/0.4)
Start Date:
January 2016
Sponsor:
Assiut University
For More Information:
https://clinicaltrials.gov/show/NCT02622126