Effects of High-Intensity Interval Training (HIT) While in a Hyperoxic-Hyperbaric Environment on Exercise Performance (HITOP Study)
Description:
The purpose of this research study is to determine the incremental benefit of high intensity
interval training (HIT) in a hyperbaric-hyperoxic environment with HIT alone in healthy
subjects and to compare the effect of HIT at an intermediate altitude (SLC, UT; altitude 1420
m) with that performed at sea-level (Durham, NC) in healthy subjects. While VO2 max is
determined by the functional interdependence of the respiratory, cardiovascular and muscular
systems, ultimately VO2 max is determined by mitochondrial oxidative capacity. Exercise
training increases mitochondrial capacity. There is evidence that high intensity interval
training (HIT) programs are effective at increasing exercise capacity. Furthermore, there is
evidence that training while in a hyperbaric-hyperoxic environment may potentiate the HIT
training effect through its effects on mitochondrial oxidative capacity, but this has not
been scientifically tested. Our hypothesis is that high intensity interval training (HIT) in
a hyperoxichyperbaric environment performed six-times over a two-week period will increase
exercise performance compared with HIT performed in ambient conditions in healthy subjects.
The primary outcome studied will be the effect of high-volume interval training in a
hyperbaric-hyperoxic on VO2max.
Condition:
Exercise Performance
Treatment:
Hyperbaric chamber
Start Date:
April 14, 2016
Sponsor:
Intermountain Health Care, Inc.
For More Information:
https://clinicaltrials.gov/show/NCT02941939