Effects of Repetitive Hyperbaric Oxygen Therapy in Patients With Acute Ischaemic Stroke
Description:
Study Methods:
Study Population A 60 adult (aged >18 years) patients were included with a diagnosis of acute
thromboembolic ischemic stroke within 48 hours after onset, according to clinical picture and
imaging findings by brain computed tomography (CT) without evidence of hemorrhage, upon
admission to the hospital and no patient received thrombolytic therapy.
Inclusion criteria:
Group one, HBOT group (n = 30): thirty adult patients with acute ischemic stroke will receive
conventional medical treatment ( as antiplatelet but not thrombolytic therapy) with 10
sessions of adjunctive hyperbaric oxygen therapy (HBOT) within 3-5 days after the onset of
stroke .
Compared with Group two, control group(n = 30): thirty adult patients with acute ischemic
stroke will receive conventional medical treatment alone.
The baseline clinical characteristics were similar in both groups.
Exclusion criteria:
– Patient with cerebral hemorrhage
– Patient received thrombolytic therapy
– Emphysema with carbon dioxide retention
– Pneumothorax
– Seizure disorder
– Uncontrolled high fever
Demographic Characteristics:
Adults more than 18 years, Any gender. All patients upon admission to the hospital will
provide:
Complete history taking:Age, Gender, Smoking, Alcohol consumption, Past history: diabetes
mellitus , hypertension , Chronic obstructive pulmonary disease, Epilepsy or cardiovascular
disease.
Neurological assessment use NIHSS score Blood tests:Complete blood count , Coagulation
profile, Fasting blood sugar., Renal function test (Urea and creatinine).
CT brain
Chest x-ray :
Electrocardiogram (ECG):
Condition:
Acute Stroke
Treatment:
Hyperbaric oxygen
Start Date:
March 1, 2018
Sponsor:
Kasr El Aini Hospital
For More Information:
https://clinicaltrials.gov/show/NCT03431402