Comparative Clinical Trial on the Impact of Technical Anesthetic in Uterine Tone and Fetal Heart Rate in Pregnancies With Intrauterine Growth Restriction
Description:
INTRODUCTION: The combined spinal-epidural analgesia during labor has been associated with
changes in fetal heart rate. Opinions in the literature are not fully consolidated, and some
publications have failed to show a significant increase in fetal bradycardia following the
combination lock. In addition, the question remains whether these changes found may modify
the perinatal outcome in pregnancies that occur with intrauterine growth restriction (IUGR),
since there are no studies comparing the techniques in this population.
OBJECTIVES: To estimate the effects of combined spinal-epidural analgesia and epidural
analgesia isolated on uterine basal tone and its association with the occurrence of changes
in fetal heart rate on perinatal outcome in patients with fetuses with IUGR.
METHOD: This is experimental, analytical, prospective, randomized, double-blind. It will
include 74 pregnant women with gestations occurring with IUGR or chronic uteroplacental
insufficiency of any etiology, that are still admitted to labor. Pregnant women will be
randomly divided into two groups: combined spinal-epidural analgesia and epidural analgesia
alone. The primary dependent variables to be evaluated will be the change in uterine tone and
changes in the fetal heart rate.
Condition:
Fetal Bradycardia
Treatment:
Epidural bupivacaine with vasoconstrictor 0.125%
Start Date:
July 12, 2017
Sponsor:
University of Sao Paulo General Hospital
For More Information:
https://clinicaltrials.gov/show/NCT02666794