by HBOT News | Nov 29, 2006 | Autism, Clinical Trials, HBOT Research
PURPOSE
The purpose of this investigation is to evaluate the cognitive and behavioral effects of
Hyperbaric Oxygenation Therapy in children who present with a diagnosis of autism spectrum
disorder.
HYPOTHESIS
1. Hyperbaric Oxygenation Therapy will be safe to use with children with autism.
2. Hyperbaric Oxygenation Therapy will have a statistically significant effect on the
symptoms of autism.
3. Hyperbaric Oxygenation Therapy will have a clinically significant observable effect on
the overt symptoms of autism.
4. The decreases in the symptoms of autism will correlate positively with the number of
Hyperbaric Oxygenation Therapy sessions.
5. Treatment gains obtained from Hyperbaric Oxygenation Therapy will be maintained at
follow-up, post 40 treatment sessions.
SPECIFIC AIMS
1. Provide further evidence for the safety of Hyperbaric Oxygenation Therapy in children
with autism.
2. To quantitatively assess the effects of Hyperbaric Oxygenation Therapy on behavioral and
cognitive symptoms of autism before, during, and after treatment.
3. Identify number of treatments required to reach therapeutic effects.
4. Identify the length and durability of treatment effect and maintenance.
by HBOT News | Nov 27, 2006 | Autism, Clinical Trials, HBOT Research
The purpose of this investigation is to evaluate the cognitive and behavioral effects of
Hyperbaric Oxygenation Therapy in children who present with a diagnosis of autism and other
developmental disabilities.
by HBOT News | Sep 28, 2006 | Autism, Key Autism Research
Autism is a neurodevelopmental disorder currently affecting as many as 1 out of 166 children in the United States. Numerous studies of autistic individuals have revealed evidence of cerebral hypoperfusion, neuroinflammation and gastrointestinal inflammation, immune dysregulation, oxidative stress, relative mitochondrial dysfunction, neurotransmitter abnormalities, impaired detoxification of toxins, dysbiosis, and impaired production of porphyrins. Many of these findings have been correlated with core autistic symptoms. For example, cerebral hypoperfusion in autistic children has been correlated with repetitive, self-stimulatory and stereotypical behaviors, and impairments in communication, sensory perception, and social interaction.
by HBOT News | Nov 21, 2005 | Autism, Clinical Trials, HBOT Research
This study will look at the changes taking place in the blood levels of key markers of
oxidative stress. Oxidative stress is the biological equivalent of rust on a car. It changes
vital cell chemistry. It is known to occur at high pressure oxygen, but little is known about
changes at pressures slightly greater than normal atmospheric pressure.
Hyperbaric therapy is used in a variety of medical conditions. It is being tested in this
study only for safety. It is not being assessed for the ability of hyperbaric oxygen to
improve the clinical condition of children with autism.
This study was felt to be important since autism appears to be associated with oxidative
stress and hyperbarics was being used "off-label" for this condition without safety studies.
