Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery.
Abstract: Brain radionecrosis (tissue death caused by radiation) can occur following high-dose radiotherapy to brain tissue and can have a significant impact on a person’s quality of life (QoL) and function. The underlying pathophysiological mechanism remains...Clinical trials targeting hypoxia.
Abstract: The concept of tumour hypoxia as a cause of radiation resistance has been prevalent for over 100 years. During this time, our understanding of tumour hypoxia has matured with the recognition that oxygen tension within a tumour is influenced by both diffusion...Nontoxic Targeting of Energy Metabolism in Preclinical VM-M3 Experimental Glioblastoma.
Abstract: Temozolomide (TMZ) is part of the standard of care for treating glioblastoma multiforme (GBM), an aggressive primary brain tumor. New approaches are needed to enhance therapeutic efficacy and reduce toxicity. GBM tumor cells are dependent on glucose and...Clinical Trial – Hyperbaric Oxygenation Treatment and Quality of Life
Osteoradionecrosis, dermal soft tissue necrosis, radiation cystitis, proctitis and sexual
dysfunctions are well-known late-effects after radiation for cancer in the pelvic area,
negatively affecting the survivors’ quality of life (QOL) and psychosocial wellbeing.
Increasing evidence and clinical practice support the use of hyperbaric oxygen treatment
(HBOT) as an effective treatment in a variety of radiation injuries, but this is still a
field with limited research and knowledge. Especially, there is a knowledge gap on how late
radiation tissue injury (LRTI) influences cancer survivors’ QOL and psychosocial health in a
longitudinal perspective (before, along and after HBOT), as well as the patients’ knowledge,
expectation and experience from this treatment. This study aims to improve knowledge on these
issues.