MEK inhibitors induce Akt activation and drug resistance by suppressing negative feedback ERK-mediated HER2 phosphorylation at Thr701.
Abstract: Targeting the MEK/ERK pathway has been viewed as a promising strategy for cancer therapy. However, MEK inhibition leads to the compensatory PI3K/AKT activation and thus contributes to the desensitization of cancer cells to MEK inhibitors. The underlying...Interventional pulmonology for patients with central airway obstruction: An 8-year institutional experience.
Abstract: Patients with central airway obstruction (CAO) may need endobronchial intervention to relieve their symptoms. This report is on a single-center experience of using interventional bronchoscopy in terms of complications and survival. This retrospective study...Clinical Trial – Effect of Intrathecal Morphine, Dexmedetomidine or Both in Combination to Bupivacaine on Immunity
this work aims to investigate the effect of intrathecal administration of Morphine,
Dexmedetomidine or both in combination on cellular immunity and cytokine production in
patients undergoing major abdominal cancer surgeries.