Clinical Trial – Effect of Intravenous Magnesium on Post-spinal Fentanyl Induced Pruritus Incidence
Introduction: Adding opioids to local anesthetic solutions leads to enhanced anesthesia and
provide postoperative analgesia. Intrathecaly injected opioids have some side effects,
though. One of them is pruritus. Objective: We designed a randomized, double‐blinded,
placebo‐controlled study to evaluate prophylactic impact of continuous IV Magnesium 10mg/kg
over 30 minutes on intrathecal fentanyl‐induced pruritus start at the end of the operation.
Methods: ASA I‐II Patient’s candidate for orthopedic operations under spinal anesthesia
(10‐15mg hyperbaric bupivacaine and 25 µg fentanyl intrathecal) and will be divided randomly
into two groups:
Control group (Placebo group): bolus 100 ml nacl 0.9% at end of surgery Study group (Mg ++
group): (continuous IV Magnesium 10mg/kg in 100 ml Nacl0.9% over 30 minutes at end of
surgery).
Study outcome:
1. Hemodynamics: Systolic blood pressure, Mean arterial blood pressure, pulse rate, O2
saturation will be recorded in 5 min,10 min,30 min,60 min and every one hour till 6
hours after the operation.
2. Pruritus Patients were asked about existence (present=1,no=0), severity (mild=1,
modret=2, sever =3) and site of pruritus (Face(trigeminal) =1, neuroaxial(dermatome)=2),
1,2,4, and 6 hours after operation. Incidence of pruritus total group incidence %.
3. The incidence of PONV.
Hyperbaric oxygen therapy benefits in concussion management
Many Oklahomans suffer from debilitating conditions resulting from head trauma. Brain injuries may result from active duty military service, sports activities, automobile accidents, and from a host of other traumatic events. State Rep. Jay Steagall (R-Yukon), chair of...Clinical Trial – Effect of Intravenous Dexmedetomidine on Patient Discomfort in Laparoscopic Cholecystectomy Under Spinal Anesthesia.
Laparoscopic cholecystectomy (LC) has been routinely performed under general anesthesia
despite the several disadvantages of general anesthesia compared to regional anesthesia.
There are multiple reports that have been published regarding the feasibility of spinal
anesthesia for LC associated with many problems such as referred shoulder pain secondary to
intra-abdominal pneumoperitoneum; patient anxiety, pain, and discomfort; and inadequate
sedation.The aim of our study is to prospectively observe the feasibility of using
intravenous dexmedetomidine to abolish patient discomfort and shoulder pain, thus making the
patient more comfortable without causing excessive sedation and respiratory depression.
Clinical Trial – Comparison of Clorotekal and Bupivacaine for Short Obstetric Surgery
The following obstetric procedures are commonly performed with spinal anesthesia on labor and
delivery: bilateral tubal ligation, external cephalic version, cerclage insertion, cerclage
removal, minimally invasive fetal surgery, and evacuation of retained products of conception.
Bupivacaine is currently the standard spinal medication for these procedures because of its
long history of safe use, its low incidence of transient neurologic symptoms, and its ability
to provide a dependable, dense block with a high degree of maternal satisfaction. While
bupivacaine has the aforementioned advantages, it unfortunately has a long duration of
action, up to 240-380 minutes, which far exceeds the time necessary to complete most
obstetric procedures. Clorotekal®, the first Food and Drug Administration approved
chloroprocaine solution created for spinal injection, is a potential alternative. When
compared with bupivacaine spinals, chloroprocaine spinals have been shown to facilitate
clinically significant shorter times to resolution of motor and sensory block, first
ambulation, micturition, and discharge readiness. The objective of this study is to determine
if a strategy of spinal anesthesia with chloroprocaine will reduce the duration of motor
block, compared with equivalent block with hyperbaric bupivacaine..