Clinical Trial – Hemodynamic Effects of Low Dose Spinal Anesthesia for Cesarean Section
We propose to study the effects on hemodynamics (blood pressure, cardiac output, and central
venous pressure) of two doses of bupivacaine for spinal anesthesia during cesarean section: a
higher dose of 12 mg to a lower dose of 4.5 mg. We will examine recovery times, incidence of
hypotension, and compare pain control and maternal satisfaction during and after cesarean
section.
We hypothesize that low dose bupivacaine spinal anesthesia will provide equivalent anesthesia
for cesarean section compared to conventional dose bupivacaine, with less hypotension, faster
recovery time, and enhanced maternal satisfaction. Maternal satisfaction will be assessed by
self-reported pain scores, incidence of nausea and vomiting, shivering, and ability to
interact with baby in the OR.
Effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving.
Abstract: Hyperbaric oxygen preconditioning (HBO-PC) can protect the heart from injury during subsequent ischemia. The presence of high loads of venous gas emboli (VGE) induced by a rapid ambient pressure reduction on ascent from diving may cause ischemia and acute...Clinical Trial – ET50 With Fentanyl for Post Caesarean Section Spinal Hypotension
Hypotension is extremely common after induction of spinal anesthesia for cesarean delivery.
Anesthetic blockade of the sympathetic outflow of the spinal cord causes vasodilation, and is
one cause of this hypotension. The higher the spread of the blockade will result in a higher
incidence of hypotension. Injected hyperbaric medication has about 15 minutes to spread
within the intrathecal space before it will be taken up by the nerve roots. The time that a
patient remains in one position after medication injection will affect the spread of the
resultant anesthetic block. A patient who is left sitting for a longer period of time after
injection of hyperbaric medication will have a lower level of block than someone who is
placed supine immediately. In this study, the investigators wish to use up down sequential
analysis to determine the time period a patient should remain seated after intrathecal
injection of hyperbaric bupivacaine and fentanyl that will result in a 50% rate of
hypotension.
Clinical Trial – Comparative Study Between Bilateral and Unilateral Spinal Anaesthesia
The purpose of this study is to compare unilateral spinal anesthesia using hyperbaric
Prilocaine with "classical bilateral spinal anesthesia" using plain Prilocaine according to
block characteristics and quality of micturition, standardized to the subjects own functional
bladder capacity. Our hypothesis is that unilateral spinal anesthesia will provide faster
time to micturtition and discharge, lesser hypotension and lesser micturition problems.