Clinical Trial – Hyperbaric Hyperoxygenation With Radiotherapy and Temozolomide in Adults With Newly Diagnosed Glioblastoma
Standard treatment for glioblastomas includes radiation and chemotherapy with a drug called
temozolomide (Temodar); however, glioblastomas frequently develop resistance to standard
treatment and recur or progress. Glioblastomas are known to have decreased levels of oxygen
compared to normal tissues. There is evidence that these lower oxygen levels in glioblastomas
may contribute to their ability to resist treatment effects of radiation and chemotherapy. In
this study we will look to increase the oxygen concentration within the glioblastoma by
adding hyperbaric treatments (the experimental part of this study) to standard treatment with
radiation and temozolomide in order to see whether increasing the oxygen concentration within
the tumor increases the tumor-killing ability of standard radiation and chemotherapy.
In addition, the investigators are interested to evaluate the effect of this treatment
protocol on a person’s quality of life and level of stress, and, therefore, the investigators
will ask subjects to complete several brief questionnaires while they are on-study.
[Continuous spinal block in a patient undergoing partial gastrectomy: case report].
Abstract: Due to the high incidence of technical and neurological complications, continuous spinal blocks were not performed for several years. With the advent of intermediate catheters the technique has been used more often and gaining acceptance among...Clinical Trial – Hyperbaric Oxygen Treatment of Mandibular Osteoradionecrosis. A Randomized Clinical Study
There is currently not sufficient evidence that hyperbaric oxygen (HBO) benefits the surgical
removal of necrotic bone in osteoradionecrosis patients. This study aims at testing the
hypothesis that HBO does improve healing after surgical removal of necrotic bone in
irradiated previous head and neck cancer patients compared to not receiving HBO.
Clinical Trial – The Effect of Hyperbaric Oxygen Therapy on Patients Suffering From Neurologic Deficiency Due Traumatic Brain Injury
Traumatic brain injuries (TBI) are a major cause of morbidity and mortality worldwide. Due to
improvements in emergency medical care, transportation and specialized trauma facilities, the
number of people surviving TBI with impairment has significantly increased in recent years.
The long term cognitive sequelae, which are often not visible persist far beyond the
resolution of the obvious physical disabilities. This combined with the relatively low
awareness of the general public has designated TBI as the "silent epidemic" (TBI CDC 2006).
Hyperbaric oxygen therapy (HBOT) has been suggested as a possible treatment modality for
these cases and preliminary studies are promising.
The purpose of this study is to evaluate the effectiveness of HBOT in the treatment of
chronic mild traumatic brain injuries (mTBI). Sequential SPECT scans of the brain and
neurocognitive testing will be used to evaluate cerebral blood flow (CBF) response, cognitive
and functional improvement following treatment.