Clinical Trial – Effect of Hyperbaric Therapy on Markers of Oxidative Stress in Children With Autism

This study will look at the changes taking place in the blood levels of key markers of
oxidative stress. Oxidative stress is the biological equivalent of rust on a car. It changes
vital cell chemistry. It is known to occur at high pressure oxygen, but little is known about
changes at pressures slightly greater than normal atmospheric pressure.

Hyperbaric therapy is used in a variety of medical conditions. It is being tested in this
study only for safety. It is not being assessed for the ability of hyperbaric oxygen to
improve the clinical condition of children with autism.

This study was felt to be important since autism appears to be associated with oxidative
stress and hyperbarics was being used "off-label" for this condition without safety studies.